open access

Vol 65, No 4 (2014)
Original papers
Published online: 2014-08-29
Submitted: 2014-08-29
Accepted: 2014-08-29
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VEGF-A and PDGF-BB — angiogenic factors and the stage of diabetic foot syndrome advancement

Ewelina Drela, Arleta Kulwas, Wiesław Jundziłł, Barbara Góralczyk, Joanna Boinska, Wanda Drewniak, Grażyna Gadomska, Danuta Rość
DOI: 10.5603/EP.2014.0042
·
Endokrynologia Polska 2014;65(4):306-312.

open access

Vol 65, No 4 (2014)
Original papers
Published online: 2014-08-29
Submitted: 2014-08-29
Accepted: 2014-08-29

Abstract

Introduction: In patients with diabetic foot syndrome (DFS), an inadequate angiogenic response is observed. The aim of this study was to evaluate the concentrations of VEGF-A, PDGF-BB, sVEGF-R2 and sVEGF-R1 in patients with diabetes-complicated diabetic foot syndrome and analyse them using selected clinical data.

Material and methods: Forty seven diabetic patients, 25 women mean age 63 and 20 men mean age 60.5, with diabetic foot syndrome (DFS) were enrolled in the experimental group. To evaluate angiogenesis factors depending on Wagner grade, the subjects were divided into three subgroups: I — patients with 0 Wagner grade (n = 14); II — patients with 1,2,3 Wagner grades (n = 15); and III — patients with 4,5 Wagner grades (n = 18). The control group consisted of 20 healthy volunteers. The material for research was blood.

Results: Significantly higher levels of VEGF-A and PDGF-BB in the DFS cases compared to controls were observed (VEGF-A p = 0.000001; PDGF-BB p = 0.000051). Analysis of angiogenic parameters according to the stage of diabetic foot syndrome advancement showed higher VEGF-A level (I: p = 0.000867; II: p = 0.001827; III: p = 0.000024) and PDGF-BB (respectively p = 0.004113, p = 0.004224, p = 0.002480) in all the subgroups. Decreased sVEGF-R2 concentrations were observed in the I (p = 0.054) subgroup and the III (p = 0.03524) subgroup. In this study, a strong positive correlation between VEGF-A and PDGF-BB was observed (R = 0.66; p = 0.000001).

Conclusions: Our study revealed that proangiogenic factor levels were increased in DFS. This is associated with lower limb ischaemia and hypoxic conditions. The stage of diabetic foot syndrome advancement influenced VEGF-A and PDGF-BB concentrations. (Endokrynol Pol 2014; 65 (4):306–312)

Abstract

Introduction: In patients with diabetic foot syndrome (DFS), an inadequate angiogenic response is observed. The aim of this study was to evaluate the concentrations of VEGF-A, PDGF-BB, sVEGF-R2 and sVEGF-R1 in patients with diabetes-complicated diabetic foot syndrome and analyse them using selected clinical data.

Material and methods: Forty seven diabetic patients, 25 women mean age 63 and 20 men mean age 60.5, with diabetic foot syndrome (DFS) were enrolled in the experimental group. To evaluate angiogenesis factors depending on Wagner grade, the subjects were divided into three subgroups: I — patients with 0 Wagner grade (n = 14); II — patients with 1,2,3 Wagner grades (n = 15); and III — patients with 4,5 Wagner grades (n = 18). The control group consisted of 20 healthy volunteers. The material for research was blood.

Results: Significantly higher levels of VEGF-A and PDGF-BB in the DFS cases compared to controls were observed (VEGF-A p = 0.000001; PDGF-BB p = 0.000051). Analysis of angiogenic parameters according to the stage of diabetic foot syndrome advancement showed higher VEGF-A level (I: p = 0.000867; II: p = 0.001827; III: p = 0.000024) and PDGF-BB (respectively p = 0.004113, p = 0.004224, p = 0.002480) in all the subgroups. Decreased sVEGF-R2 concentrations were observed in the I (p = 0.054) subgroup and the III (p = 0.03524) subgroup. In this study, a strong positive correlation between VEGF-A and PDGF-BB was observed (R = 0.66; p = 0.000001).

Conclusions: Our study revealed that proangiogenic factor levels were increased in DFS. This is associated with lower limb ischaemia and hypoxic conditions. The stage of diabetic foot syndrome advancement influenced VEGF-A and PDGF-BB concentrations. (Endokrynol Pol 2014; 65 (4):306–312)

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Keywords

angiogenesis; diabetic foot syndrome; vascular endothelial growth factor; platelet-derived growth factor

About this article
Title

VEGF-A and PDGF-BB — angiogenic factors and the stage of diabetic foot syndrome advancement

Journal

Endokrynologia Polska

Issue

Vol 65, No 4 (2014)

Pages

306-312

Published online

2014-08-29

DOI

10.5603/EP.2014.0042

Bibliographic record

Endokrynologia Polska 2014;65(4):306-312.

Keywords

angiogenesis
diabetic foot syndrome
vascular endothelial growth factor
platelet-derived growth factor

Authors

Ewelina Drela
Arleta Kulwas
Wiesław Jundziłł
Barbara Góralczyk
Joanna Boinska
Wanda Drewniak
Grażyna Gadomska
Danuta Rość

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