open access

Vol 65, No 4 (2014)
Original papers
Published online: 2014-08-29
Submitted: 2014-08-29
Accepted: 2014-08-29
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The prevalence of Wolfram syndrome in a paediatric population with diabetes

Agnieszka Zmysłowska, Maciej Borowiec, Wojciech Fendler, Przemysława Jarosz-Chobot, Małgorzata Myśliwiec, Agnieszka Szadkowska, Wojciech Młynarski
DOI: 10.5603/EP.2014.0040
·
Endokrynologia Polska 2014;65(4):295-297.

open access

Vol 65, No 4 (2014)
Original papers
Published online: 2014-08-29
Submitted: 2014-08-29
Accepted: 2014-08-29

Abstract

Introduction: Wolfram syndrome (WFS) is the most frequent syndromic form of monogenic diabetes coexisting with optic atrophy and many other disorders. The aim of this study was to estimate the prevalence of Wolfram syndrome among children with diabetes in Poland.

Material and methods: These calculations were performed among Polish diabetic children, aged 0–18 years, from three administrative regions between January 2005 and December 2011. Epidemiological data was obtained by matching the results from the EURO-WABBPoland Project and the PolPeDiab Registry.

Results: Throughout the study period, we confirmed genetic diagnosis of Wolfram syndrome in 13 patients from Poland. Three patients originated from the studied regions with complete epidemiological data on paediatric diabetes. The total number of patients with diagnosed diabetes in the study equalled 2,568 cases. The prevalence of Wolfram syndrome among Polish children with diabetes is 0.12% (95% Confidence Interval 0.04–0.34%).

Conclusions: We estimate that Wolfram syndrome is 26 to 35 times less frequent than monogenic diabetes (MODY and neonatal diabetes) in the Polish paediatric population. (Endokrynol Pol 2014; 65 (4): 295–297)

Abstract

Introduction: Wolfram syndrome (WFS) is the most frequent syndromic form of monogenic diabetes coexisting with optic atrophy and many other disorders. The aim of this study was to estimate the prevalence of Wolfram syndrome among children with diabetes in Poland.

Material and methods: These calculations were performed among Polish diabetic children, aged 0–18 years, from three administrative regions between January 2005 and December 2011. Epidemiological data was obtained by matching the results from the EURO-WABBPoland Project and the PolPeDiab Registry.

Results: Throughout the study period, we confirmed genetic diagnosis of Wolfram syndrome in 13 patients from Poland. Three patients originated from the studied regions with complete epidemiological data on paediatric diabetes. The total number of patients with diagnosed diabetes in the study equalled 2,568 cases. The prevalence of Wolfram syndrome among Polish children with diabetes is 0.12% (95% Confidence Interval 0.04–0.34%).

Conclusions: We estimate that Wolfram syndrome is 26 to 35 times less frequent than monogenic diabetes (MODY and neonatal diabetes) in the Polish paediatric population. (Endokrynol Pol 2014; 65 (4): 295–297)

Get Citation

Keywords

Wolfram syndrome; monogenic diabetes; type 1 diabetes

About this article
Title

The prevalence of Wolfram syndrome in a paediatric population with diabetes

Journal

Endokrynologia Polska

Issue

Vol 65, No 4 (2014)

Pages

295-297

Published online

2014-08-29

DOI

10.5603/EP.2014.0040

Bibliographic record

Endokrynologia Polska 2014;65(4):295-297.

Keywords

Wolfram syndrome
monogenic diabetes
type 1 diabetes

Authors

Agnieszka Zmysłowska
Maciej Borowiec
Wojciech Fendler
Przemysława Jarosz-Chobot
Małgorzata Myśliwiec
Agnieszka Szadkowska
Wojciech Młynarski

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