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Vol 65, No 3 (2014)
Review paper
Submitted: 2014-06-27
Accepted: 2014-06-27
Published online: 2014-06-27
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The role of fat mass and obesity-associated gene (FTO) in obesity — an overview

Aleksandra Zdrojowy-Wełna, Małgorzata Tupikowska, Katarzyna Kolackov, Grażyna Bednarek-Tupikowska
DOI: 10.5603/EP.2014.0031
·
Endokrynol Pol 2014;65(3):224-231.

open access

Vol 65, No 3 (2014)
Review Article
Submitted: 2014-06-27
Accepted: 2014-06-27
Published online: 2014-06-27

Abstract

Obesity is an epidemic of the 21st century. The magnitude of this problem stems from its increasing prevalence and numerous metabolic complications caused by excessive fat accumulation. The pathogenesis involves both environmental and genetic factors, and FTO (fat massand obesity-associated gene) is one of the most significant among genes predisposing to obesity. The role of FTO polymorphism in the development of obesity has been confirmed in many studies, but the effect varies significantly in different ethnic groups. Moreover, the exact mechanisms of FTO influence are yet to be explained. The association between FTO and lifestyle factors such as diet and physical activity has been extensively studied in recent years. This paper presents current knowledge about the role of FTO gene in the development of obesity and type 2 diabetes in different ethnic groups and the association between FTO polymorphism and lifestyle modifications predisposing to adiposity.

Abstract

Obesity is an epidemic of the 21st century. The magnitude of this problem stems from its increasing prevalence and numerous metabolic complications caused by excessive fat accumulation. The pathogenesis involves both environmental and genetic factors, and FTO (fat massand obesity-associated gene) is one of the most significant among genes predisposing to obesity. The role of FTO polymorphism in the development of obesity has been confirmed in many studies, but the effect varies significantly in different ethnic groups. Moreover, the exact mechanisms of FTO influence are yet to be explained. The association between FTO and lifestyle factors such as diet and physical activity has been extensively studied in recent years. This paper presents current knowledge about the role of FTO gene in the development of obesity and type 2 diabetes in different ethnic groups and the association between FTO polymorphism and lifestyle modifications predisposing to adiposity.

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Keywords

obesity; fat mass and obesity-associated gene; polymorphism; ethnicity; lifestyle modifications

About this article
Title

The role of fat mass and obesity-associated gene (FTO) in obesity — an overview

Journal

Endokrynologia Polska

Issue

Vol 65, No 3 (2014)

Article type

Review paper

Pages

224-231

Published online

2014-06-27

Page views

3387

Article views/downloads

4795

DOI

10.5603/EP.2014.0031

Bibliographic record

Endokrynol Pol 2014;65(3):224-231.

Keywords

obesity
fat mass and obesity-associated gene
polymorphism
ethnicity
lifestyle modifications

Authors

Aleksandra Zdrojowy-Wełna
Małgorzata Tupikowska
Katarzyna Kolackov
Grażyna Bednarek-Tupikowska

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