open access

Vol 66, No 2 (2015)
Original papers
Published online: 2015-05-01
Submitted: 2014-07-01
Accepted: 2014-10-16
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Comparison of the effects of short-term hypolipidaemic treatment on plasma adipokine levels in men and women with isolated hypercholesterolaemia

Robert Krysiak, Witold Żmuda, Bogdan Marek, Bogusław Okopień
DOI: 10.5603/EP.2015.0017
·
Endokrynologia Polska 2015;66(2):114-120.

open access

Vol 66, No 2 (2015)
Original papers
Published online: 2015-05-01
Submitted: 2014-07-01
Accepted: 2014-10-16

Abstract

Introduction: Hypolipidaemic agents were found to affect plasma adipokine levels, but no previous study has investigated whether this effect is sex-dependent.
Material and methods: We retrospectively analysed 61 patients participating in our previous studies, who because of isolated hypercholesterolaemia were treated with simvastatin (40 mg daily), ezetimibe (10 mg daily) or simvastatin (40 mg daily) plus ezetimibe (10 mg daily). Plasma levels of leptin, adiponectin, visfatin, tumour necrosis factor-alpha (TNF-alpha), free fatty acids (FFA), and high-sensitivity C-reactive protein (hsCRP) were assessed separately for men and women before and after 30 days of treatment.
Results: At baseline, plasma levels of adiponectin and leptin were lower, while plasma levels of TNF-alpha were higher in men than in women. Administration of simvastatin and statin/ezetimibe combination for 30 days reduced plasma levels of hsCRP, FFA, leptin, visfatin, and TNF-alpha but increased plasma levels of adiponectin, while the effect of ezetimibe was much more limited. The effect of simvastatin and ezetimibe, administered alone or in combination, on plasma hsCRP, FFA, leptin, adiponectin, visfatin, and TNF-alpha did not differ between men and women. Irrespectively of sex, the changes in plasma adipokines and systemic-anti-inflammatory effects were more expressed in simvastatin — than in ezetimibe-treated patients and were strongest when both these agents were administered together.
Conclusions: Our results show that sex differences do not determine the effect of hypolipidaemic agents on adipose tissue and low-grade inflammation. (Endokrynol Pol 2015; 66 (2): 114–120)

Abstract

Introduction: Hypolipidaemic agents were found to affect plasma adipokine levels, but no previous study has investigated whether this effect is sex-dependent.
Material and methods: We retrospectively analysed 61 patients participating in our previous studies, who because of isolated hypercholesterolaemia were treated with simvastatin (40 mg daily), ezetimibe (10 mg daily) or simvastatin (40 mg daily) plus ezetimibe (10 mg daily). Plasma levels of leptin, adiponectin, visfatin, tumour necrosis factor-alpha (TNF-alpha), free fatty acids (FFA), and high-sensitivity C-reactive protein (hsCRP) were assessed separately for men and women before and after 30 days of treatment.
Results: At baseline, plasma levels of adiponectin and leptin were lower, while plasma levels of TNF-alpha were higher in men than in women. Administration of simvastatin and statin/ezetimibe combination for 30 days reduced plasma levels of hsCRP, FFA, leptin, visfatin, and TNF-alpha but increased plasma levels of adiponectin, while the effect of ezetimibe was much more limited. The effect of simvastatin and ezetimibe, administered alone or in combination, on plasma hsCRP, FFA, leptin, adiponectin, visfatin, and TNF-alpha did not differ between men and women. Irrespectively of sex, the changes in plasma adipokines and systemic-anti-inflammatory effects were more expressed in simvastatin — than in ezetimibe-treated patients and were strongest when both these agents were administered together.
Conclusions: Our results show that sex differences do not determine the effect of hypolipidaemic agents on adipose tissue and low-grade inflammation. (Endokrynol Pol 2015; 66 (2): 114–120)

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Keywords

sex; simvastatin; ezetimibe; hypercholesterolaemia; leptin; adiponectin; visfatin; tumour necrosis factor-alpha (TNF-alpha)

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About this article
Title

Comparison of the effects of short-term hypolipidaemic treatment on plasma adipokine levels in men and women with isolated hypercholesterolaemia

Journal

Endokrynologia Polska

Issue

Vol 66, No 2 (2015)

Pages

114-120

Published online

2015-05-01

DOI

10.5603/EP.2015.0017

Bibliographic record

Endokrynologia Polska 2015;66(2):114-120.

Keywords

sex
simvastatin
ezetimibe
hypercholesterolaemia
leptin
adiponectin
visfatin
tumour necrosis factor-alpha (TNF-alpha)

Authors

Robert Krysiak
Witold Żmuda
Bogdan Marek
Bogusław Okopień

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