open access

Vol 65, No 6 (2014)
Original papers
Published online: 2014-12-31
Submitted: 2014-03-29
Accepted: 2014-05-05
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Accumulation of abdominal fat in relation to selected proinflammatory cytokines concentrations in non-obese Wrocław inhabitants

Grażyna Bednarek-Tupikowska, Aleksandra Zdrojowy-Wełna, Barbara Stachowska, Justyna Kuliczkowska-Płaksej, Magdalena Matczak-Giemza, Eliza Kubicka, Urszula Tworowska-Bardzińska, Andrzej Milewicz, Marek Bolanowski
DOI: 10.5603/EP.2014.0062
·
Endokrynologia Polska 2014;65(6):449-455.

open access

Vol 65, No 6 (2014)
Original papers
Published online: 2014-12-31
Submitted: 2014-03-29
Accepted: 2014-05-05

Abstract

Introduction: Metabolically obese normal weight (MONW) subjects, despite their normal BMI, present metabolic disturbances characteristic of abdominal obesity. One of the reasons might be subclinical inflammation caused by the fat tissue excess. The aim of this study was to assess the association between the accumulation of fat (especially abdominal) and the concentration of selected proinflammatory cytokines — interleukins (IL-6, IL-18) and C-reactive protein (CRP).

Material and methods: The study population consisted of 342 subjects (218 women, 124 men; age 20–40 years, BMI < 27 kg/m2) recruited from a community centre in Wroclaw. The group was divided based on the homeostasis assessment insulin resistance index (HOMA) value: 90 MONW subjects with HOMA > 1.69 and 252 subjects as control group. Anthropometric parameters, serum IL-6, IL-18, CRP, glucose, insulin concentrations and insulin sensitivity/resistance indexes were evaluated.

Results: CRP levels were significantly higher (3.26 vs. 1.97, p = 0.03) in MONW women than in the control group. Serum IL-6, IL-18 levels in males and females did not differ in both groups. IL-6 showed a significant correlation with the abdominal to gynoidal fat tissue deposit ratio in women. There were correlations between the CRP and BMI, WHR, waist circumference, total fat, abdominal fat deposit, and abdominal to gynoidal fat deposit ratio in both sexes. In women, positive correlations between CRP and HOMA, FIRI and negative with QUICKI index were present.

Conclusions: Increased accumulation of abdominal adipose tissue in non-obese, young and healthy subjects is related to increased CRP levels. (Endokrynol Pol 2014; 65 (6): 449–455)

Abstract

Introduction: Metabolically obese normal weight (MONW) subjects, despite their normal BMI, present metabolic disturbances characteristic of abdominal obesity. One of the reasons might be subclinical inflammation caused by the fat tissue excess. The aim of this study was to assess the association between the accumulation of fat (especially abdominal) and the concentration of selected proinflammatory cytokines — interleukins (IL-6, IL-18) and C-reactive protein (CRP).

Material and methods: The study population consisted of 342 subjects (218 women, 124 men; age 20–40 years, BMI < 27 kg/m2) recruited from a community centre in Wroclaw. The group was divided based on the homeostasis assessment insulin resistance index (HOMA) value: 90 MONW subjects with HOMA > 1.69 and 252 subjects as control group. Anthropometric parameters, serum IL-6, IL-18, CRP, glucose, insulin concentrations and insulin sensitivity/resistance indexes were evaluated.

Results: CRP levels were significantly higher (3.26 vs. 1.97, p = 0.03) in MONW women than in the control group. Serum IL-6, IL-18 levels in males and females did not differ in both groups. IL-6 showed a significant correlation with the abdominal to gynoidal fat tissue deposit ratio in women. There were correlations between the CRP and BMI, WHR, waist circumference, total fat, abdominal fat deposit, and abdominal to gynoidal fat deposit ratio in both sexes. In women, positive correlations between CRP and HOMA, FIRI and negative with QUICKI index were present.

Conclusions: Increased accumulation of abdominal adipose tissue in non-obese, young and healthy subjects is related to increased CRP levels. (Endokrynol Pol 2014; 65 (6): 449–455)

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Keywords

metabolically obese but normal weight subjects; subclinical inflammation; proinflammatory cytokines

About this article
Title

Accumulation of abdominal fat in relation to selected proinflammatory cytokines concentrations in non-obese Wrocław inhabitants

Journal

Endokrynologia Polska

Issue

Vol 65, No 6 (2014)

Pages

449-455

Published online

2014-12-31

DOI

10.5603/EP.2014.0062

Bibliographic record

Endokrynologia Polska 2014;65(6):449-455.

Keywords

metabolically obese but normal weight subjects
subclinical inflammation
proinflammatory cytokines

Authors

Grażyna Bednarek-Tupikowska
Aleksandra Zdrojowy-Wełna
Barbara Stachowska
Justyna Kuliczkowska-Płaksej
Magdalena Matczak-Giemza
Eliza Kubicka
Urszula Tworowska-Bardzińska
Andrzej Milewicz
Marek Bolanowski

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