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Functional polymorphisms of the leptin and leptin receptor genes are associated with longevity and with the risk of myocardial infarction and of type 2 diabetes mellitus
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Abstract
Introduction: Longevity is commonly associated with good health and with delayed onset of age-related diseases with usually benign course. Leptin (LEP) significantly affects metabolism and numerous functions of the organism. To find out if extreme longevity and its phenotype are associated with genetic variants of leptin and leptin receptor (LEPR) genes, we analysed the frequencies of the –2548 G/A and +19 G/A LEP, as well as the K109R, Q223R, and K656N LEPR polymorphisms in centenarians and in control groups.
Material and methods: The frequencies of the LEP and LEPR polymorphisms were tested by restriction fragment length polymorphism in 128 centenarians, 414 young controls (Y), 226 myocardial infarction (MI) patients, and 190 type 2 diabetes mellitus (DM2) patients.
Results: The GG genotype of the –2548 G/A LEP polymorphism was significantly more common in centenarians than in the Y, MI and DM2 groups (p = 0.048, p = 0.003, p = 0.049, respectively). In addition, the AA genotype of the K109R LEPR polymorphism was significantly less frequent in centenarians than in the Y, MI, and DM2 groups (p = 0.026, p = 0.013, and p = 0.001, respectively).
Conclusions: We suggest that the leptin pathway plays a role in the regulation of longevity, possibly by modulating the risk of development of MI and of DM2. (Endokrynol Pol 2014; 65 (1): 11–16)
Abstract
Introduction: Longevity is commonly associated with good health and with delayed onset of age-related diseases with usually benign course. Leptin (LEP) significantly affects metabolism and numerous functions of the organism. To find out if extreme longevity and its phenotype are associated with genetic variants of leptin and leptin receptor (LEPR) genes, we analysed the frequencies of the –2548 G/A and +19 G/A LEP, as well as the K109R, Q223R, and K656N LEPR polymorphisms in centenarians and in control groups.
Material and methods: The frequencies of the LEP and LEPR polymorphisms were tested by restriction fragment length polymorphism in 128 centenarians, 414 young controls (Y), 226 myocardial infarction (MI) patients, and 190 type 2 diabetes mellitus (DM2) patients.
Results: The GG genotype of the –2548 G/A LEP polymorphism was significantly more common in centenarians than in the Y, MI and DM2 groups (p = 0.048, p = 0.003, p = 0.049, respectively). In addition, the AA genotype of the K109R LEPR polymorphism was significantly less frequent in centenarians than in the Y, MI, and DM2 groups (p = 0.026, p = 0.013, and p = 0.001, respectively).
Conclusions: We suggest that the leptin pathway plays a role in the regulation of longevity, possibly by modulating the risk of development of MI and of DM2. (Endokrynol Pol 2014; 65 (1): 11–16)
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Keywords
leptin gene (LEP); leptin receptor gene (LEPR); polymorphism; longevity; centenarians; myocardial infarction (MI); type 2 diabetes mellitus (DM2)
About this articleTitle
Functional polymorphisms of the leptin and leptin receptor genes are associated with longevity and with the risk of myocardial infarction and of type 2 diabetes mellitus
Journal
Issue
Article type
Original paper
Pages
11-16
Published online
2014-02-19
Page views
2618
Article views/downloads
2769
DOI
10.5603/EP.2014.0002
Bibliographic record
Endokrynol Pol 2014;65(1):11-16.
Keywords
leptin gene (LEP)
leptin receptor gene (LEPR)
polymorphism
longevity
centenarians
myocardial infarction (MI)
type 2 diabetes mellitus (DM2)
Authors
Małgorzata Roszkowska-Gancarz
Alina Kurylowicz
Jacek Polosak
Małgorzata Mossakowska
Edward Franek
Monika Puzianowska-Kuźnicka
