Vol 64, No 6 (2013)
Review paper
Published online: 2013-12-31

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Diagnostic and therapeutic guidelines for gastro-entero-pancreatic neuroendocrine neoplasms (recommended by the Polish Network of Neuroendocrine Tumours)

Beata Kos-Kudła, Jolanta Blicharz-Dorniak, Daria Handkiewicz-Junak, Barbara Jarząb, Michał Jarząb, Jolanta Kunikowska, Katarzyna Kuśnierz, Robert Król, Leszek Królicki, Maciej Krzakowski, Anna Nasierowska-Guttmejer, Ewa Nowakowska-Duława, Waldemar Patkowski, Andrzej W. Szawłowski, other participants of the Consensus Conference (affiliations at the end of this section):, Elżbieta Andrysiak-Mamos, Tomasz Bednarczuk, Marek Bolanowski, Andrzej Cichocki, Jarosław Ćwikła, Andrzej Deptała, Wanda Foltyn, Marek Hartleb, Alicja Hubalewska-Dydejczyk, Barbara Jarząb, Arkadiusz Jeziorski, Dariusz Kajdaniuk, Grzegorz Kamiński, Aldona Kowalska, Paweł Lampe, Dariusz Lange, Anna Lewczuk, Magdalena Londzin-Olesik, Przemysław Majewski, Bogdan Marek, Gabriela Mełeń-Mucha, Andrzej Nowak, Joanna Pilch-Kowalczyk, Violetta Rosiek, Marek Ruchała, Sławomir Rudzki, Philippe Ruszniewski, Grażyna Rydzewska, Anna Sowa-Staszczak, Teresa Starzyńska, Katarzyna Steinhof-Radwańska, Janusz Strzelczyk, Wojciech Zajęcki, Piotr Zdunowski, Anna Zemczak
DOI: 10.5603/EP.2013.0028
Endokrynol Pol 2013;64(6):418-443.

Abstract

An increased interest in gastro-entero-pancreatic neuroendocrine neoplasms (GEP NENs) has recently been observed. These are rare neoplasms and their detection in recent years has improved. Over 50% of GEP NENs are carcinoids, and they are usually found incidentally during surgery in the small intestine and appendix and at diagnosis in distant metastases, mainly to the liver. There is a need for co-operation between specialists in various disciplines of medicine in order to work out the diagnostic and therapeutic guidelines. In this publication, we present general recommendations of the Polish Network of Neuroendocrine Tumours for the management of patients with GEP NENs, developed at the Consensus Conference which took place in Kamień Śląski in April 2013. Members of the guidelines working groups were assigned sections of the 2008 guidance to update.

In the subsequent parts of this publication, we present the rules of diagnostic and therapeutic management of:

— neuroendocrine neoplasms of the stomach and duodenum (including gastrinoma);

— pancreatic neuroendocrine neoplasms;

— neuroendocrine neoplasms of the small intestine and the appendix;

— colorectal neuroendocrine neoplasms.

The proposed recommendations by Polish and foreign experts representing different fields of medicine (endocrinology, gastroenterology, surgery, oncology, nuclear medicine and pathology) will be helpful in the diagnosis and treatment of GEP NENs patients. (Endokrynol Pol 2013; 64 (6): 418–443)