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First report on the validity of a continuous Metabolic Syndrome score as an indicator for Metabolic Syndrome in a national sample of paediatric population — the CASPIAN-III study
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Abstract
Introduction: The aim of this study was to assess the validity of a continuous Metabolic Syndrome score (cMetS) in a nationally representativesample of Iranian children and to identify sex and age-specific optimal cut-off points of cMetS that are associated with MetS.
Material and methods: This study was conducted among 3,254 schoolchildren aged 10–18 years. cMetS was derived by aggregating ageand sex-standardised residuals of waist circumference (WC), mean arterial pressure (MAP), glucose, high density lipoprotein-cholesterol(HDL-C) and triglycerides (TG). To determine the optimal cut-off points of cMetS for predicting MetS, receiver operator characteristic(ROC) curve analysis was used with an estimation of the variables’ sensitivity and specificity.
Results: A graded relationship was documented between cMetS and the number of risk factors. Increasing mean values of cMetS with increasingnumbers of components were apparent for both genders. The overall optimal cMetS cut-off point for predicting the presence of MetS was 2.93 [sensitivity= 92%, specificity = 91%, area of the curve = 0.96 (0.95–0.97)]. The values for boys and girls were 2.97 and 3.26 respectively in the total study.
Conclusion: This nationwide study confirmed the validity of the cMetS score in a population-based sample of Iranian children. cMetSappears to be an appropriate index for investigating the association between potential risk factors and MetS in epidemiological researchin Iran.
Abstract
Introduction: The aim of this study was to assess the validity of a continuous Metabolic Syndrome score (cMetS) in a nationally representativesample of Iranian children and to identify sex and age-specific optimal cut-off points of cMetS that are associated with MetS.
Material and methods: This study was conducted among 3,254 schoolchildren aged 10–18 years. cMetS was derived by aggregating ageand sex-standardised residuals of waist circumference (WC), mean arterial pressure (MAP), glucose, high density lipoprotein-cholesterol(HDL-C) and triglycerides (TG). To determine the optimal cut-off points of cMetS for predicting MetS, receiver operator characteristic(ROC) curve analysis was used with an estimation of the variables’ sensitivity and specificity.
Results: A graded relationship was documented between cMetS and the number of risk factors. Increasing mean values of cMetS with increasingnumbers of components were apparent for both genders. The overall optimal cMetS cut-off point for predicting the presence of MetS was 2.93 [sensitivity= 92%, specificity = 91%, area of the curve = 0.96 (0.95–0.97)]. The values for boys and girls were 2.97 and 3.26 respectively in the total study.
Conclusion: This nationwide study confirmed the validity of the cMetS score in a population-based sample of Iranian children. cMetSappears to be an appropriate index for investigating the association between potential risk factors and MetS in epidemiological researchin Iran.
Keywords
continuous Metabolic Syndrome score, validity, children
About this articleTitle
First report on the validity of a continuous Metabolic Syndrome score as an indicator for Metabolic Syndrome in a national sample of paediatric population — the CASPIAN-III study
Journal
Issue
Article type
Original paper
Pages
278-284
Published online
2013-09-04
Page views
2435
Article views/downloads
2816
DOI
10.5603/EP.2013.0006
Bibliographic record
Endokrynol Pol 2013;64(4):278-284.
Keywords
continuous Metabolic Syndrome score
validity
children
Authors
Gita Shafiee
Roya Kelishadi
Ramin Heshmat
Mostafa Qorbani
Mohammad Esmaeil Motlagh
Tahereh Aminaee
Gelayol Ardalan
Mahnaz Taslimi
Parinaz Poursafa
Bagher Larijani
