Vol 6, No 1 (2005): Practical Diabetology
Review article
Published online: 2005-02-17
Ghrelin — a multifunctional activities hormone
Diabetologia Praktyczna 2005;6(1):55-62.
Abstract
Ghrelin was isolated in 1999 from rat stomach. Ghrelin
is identified as the 28-amino-acid peptide. It is
a hormone secreted into the circulation from the
stomach but also synthestised in a number of tissues,
suggesting both endocrine and paracrine effects.
Ghrelin recently identified as the natural ligand for
the growth hormone secretagogue receptor, has
multiple activities in addition to stimulation of GH
secretion, including stimulation of feeding and weight
gain. These include: prolactin and ACTH secretion;
an increase in appetite; a diabetogenic effect
on carbohydrate metabolism; positive inotropic effects
on heart; vasodilatation; and effects on cell
proliferation. The possibility of chronic manipulation
of the ghrelin system on body weight, growth and
appetite remains an exciting new field of exploration.
Ghrelin has been reported to regulate energy
homeostasis. Ghrelin is mostly produced by the stomach,
although its production has been proved in
various tissues.
Keywords: ghrelingrowth hormoneobesitydiabetes