open access

Vol 10, No 3 (2021)
Other materials agreed with the Editors
Published online: 2021-02-18
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SARS-CoV uses ACE2 and CD209L receptors in infection

Fatima Rachidi
DOI: 10.5603/DK.a2021.0017
·
Clinical Diabetology 2021;10(3):243-244.

open access

Vol 10, No 3 (2021)
COVID-19 AND DIABETES
Published online: 2021-02-18

Abstract

Diabetes causes an increase in the expression of
Angiotensin-converting enzyme 2 (ACE 2). In fact, the
receptor ACE2 is a portal of entry of SARS-CoV. in this
discussion, we focus on another receiver, CD209L,
which also facilitates entry of SARS-CoV into the cell in
diabetic subjects.

Abstract

Diabetes causes an increase in the expression of
Angiotensin-converting enzyme 2 (ACE 2). In fact, the
receptor ACE2 is a portal of entry of SARS-CoV. in this
discussion, we focus on another receiver, CD209L,
which also facilitates entry of SARS-CoV into the cell in
diabetic subjects.

Get Citation

Keywords

COVID-19, diabetes, infection, immune system

About this article
Title

SARS-CoV uses ACE2 and CD209L receptors in infection

Journal

Clinical Diabetology

Issue

Vol 10, No 3 (2021)

Article type

Other materials agreed with the Editors

Pages

243-244

Published online

2021-02-18

DOI

10.5603/DK.a2021.0017

Bibliographic record

Clinical Diabetology 2021;10(3):243-244.

Keywords

COVID-19
diabetes
infection
immune system

Authors

Fatima Rachidi

References (5)
  1. Berrou J, Fougeray S, Venot M, et al. Natural killer cell function, an important target for infection and tumor protection, is impaired in type 2 diabetes. PLoS One. 2013; 8(4): e62418.
  2. Bindom SM, Lazartigues E. The sweeter side of ACE2: physiological evidence for a role in diabetes. Mol Cell Endocrinol. 2009; 302(2): 193–202.
  3. Li J, Gao J, Xu YP, et al. Zhonghua Yi XueZaZhi. Expression of severe acute respiratory syndrome coronavirus receptors, ACE2 and CD209L in different organ derived microvascular endothelial. 2007; 87(12): 833–837.
  4. Jeffers SA, Tusell SM, Gillim-Ross L, et al. CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus. Proc Natl Acad Sci U S A. 2004; 101(44): 15748–15753.
  5. Ilyas R, Wallis R, Soilleux EJ, et al. High glucose disrupts oligosaccharide recognition function via competitive inhibition: a potential mechanism for immune dysregulation in diabetes mellitus. Immunobiology. 2011; 216(1-2): 126–131.

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