Vol 10, No 3 (2021)
Other materials agreed with the Editors
Published online: 2021-02-18
SARS-CoV uses ACE2 and CD209L receptors in infection
Clin Diabetol 2021;10(3):243-244.
Abstract
Diabetes causes an increase in the expression of
Angiotensin-converting enzyme 2 (ACE 2). In fact, the
receptor ACE2 is a portal of entry of SARS-CoV. in this
discussion, we focus on another receiver, CD209L,
which also facilitates entry of SARS-CoV into the cell in
diabetic subjects.
Keywords: COVID-19diabetesinfectionimmune system
References
- Berrou J, Fougeray S, Venot M, et al. Natural killer cell function, an important target for infection and tumor protection, is impaired in type 2 diabetes. PLoS One. 2013; 8(4): e62418.
- Bindom SM, Lazartigues E. The sweeter side of ACE2: physiological evidence for a role in diabetes. Mol Cell Endocrinol. 2009; 302(2): 193–202.
- Li J, Gao J, Xu YP, et al. Zhonghua Yi XueZaZhi. Expression of severe acute respiratory syndrome coronavirus receptors, ACE2 and CD209L in different organ derived microvascular endothelial. 2007; 87(12): 833–837.
- Jeffers SA, Tusell SM, Gillim-Ross L, et al. CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus. Proc Natl Acad Sci U S A. 2004; 101(44): 15748–15753.
- Ilyas R, Wallis R, Soilleux EJ, et al. High glucose disrupts oligosaccharide recognition function via competitive inhibition: a potential mechanism for immune dysregulation in diabetes mellitus. Immunobiology. 2011; 216(1-2): 126–131.