open access

Vol 10, No 3 (2021)
Research paper
Published online: 2021-03-03
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Body mass index correlates positively with insulin resistance and secretion but inversely with insulin sensitivity in gestational diabetes

Tania Tofail, Sharmin Jahan, Mashfiqul Hasan, Fakhrul Alam, Mohammad Fariduddin, Ahmed Abu Saleh, Muhammad Abul Hasanat
DOI: 10.5603/DK.a2021.0019
·
Clinical Diabetology 2021;10(3):270-275.

open access

Vol 10, No 3 (2021)
Original articles (submitted)
Published online: 2021-03-03

Abstract

Background. To assess fasting C-peptide and insulin
indices using homeostatic model assessment (HOMA)
in gestational diabetes mellitus (GDM).
Methods. Gestational diabetes mellitus (n = 64, age:
27.02 ± 0.53 years, BMI: 26.3 ± 0.5 kg/m2; mean ±
SEM) and normal glucose tolerance NGT (n = 56, age:
26.11 ± 0.55 years, BMI: 24.4 ± 0.4 kg/m2; mean ±
SEM) screened according to WHO 2013 criteria. Glucose
was measured by oxidase method whereas fasting
insulin and C-peptide by ELISA. HOMA-IR, HOMA-B and
HOMA-%S were calculated.

Results. C-peptide was found higher in GDM compared
to NGT without any significant difference (P = 0.465).
Fasting insulin (P = 0.063) and HOMA-IR (P < 0.001)
were significantly higher while HOMA-B (P = 0.015)
and HOMA-%S (P = 0.012) were significantly lower in
GDM than those of NGT. BMI, bad obstetric history,
multiparity and blood glucose were higher (P ≤ 0.05)
in GDM while age, duration of gestation, family history
of DM did not differ (P = NS). C-peptide (0.185 ± 0.06
vs 0.331 ± 0.44; P < 0.05), fasting insulin (4.88 ± 0.74
vs 10.37 ± 0.74; P < 0.01) and HOMA-IR (1.04 ± 0.14 vs
2.48 ± 0.18; P < 0.011) as well as HOMA-B were found
lower in GDM having BMI < 23 kg/m2 than those of
GDM with BMI ≥ 23. Conversely, HOMA-%S (115.52 ±
14.63 vs 50.62 ± 3.39; P < 0.011) was higher in the
subgroup with BMI < 23 than the rest. Fasting blood
glucose (FBG) (P < 0.01) and fasting insulin (P < 0.05)
were independent predictors for GDM.

Conclusions. Fasting C-peptide did not differ between
GDM and NGT. BMI was positively related with resistance
and secretion of insulin but inversely with sensitivity.
HOMA model analyses revealed decreased insulin
sensitivity and secretory capacity in GDM than NGT.

Abstract

Background. To assess fasting C-peptide and insulin
indices using homeostatic model assessment (HOMA)
in gestational diabetes mellitus (GDM).
Methods. Gestational diabetes mellitus (n = 64, age:
27.02 ± 0.53 years, BMI: 26.3 ± 0.5 kg/m2; mean ±
SEM) and normal glucose tolerance NGT (n = 56, age:
26.11 ± 0.55 years, BMI: 24.4 ± 0.4 kg/m2; mean ±
SEM) screened according to WHO 2013 criteria. Glucose
was measured by oxidase method whereas fasting
insulin and C-peptide by ELISA. HOMA-IR, HOMA-B and
HOMA-%S were calculated.

Results. C-peptide was found higher in GDM compared
to NGT without any significant difference (P = 0.465).
Fasting insulin (P = 0.063) and HOMA-IR (P < 0.001)
were significantly higher while HOMA-B (P = 0.015)
and HOMA-%S (P = 0.012) were significantly lower in
GDM than those of NGT. BMI, bad obstetric history,
multiparity and blood glucose were higher (P ≤ 0.05)
in GDM while age, duration of gestation, family history
of DM did not differ (P = NS). C-peptide (0.185 ± 0.06
vs 0.331 ± 0.44; P < 0.05), fasting insulin (4.88 ± 0.74
vs 10.37 ± 0.74; P < 0.01) and HOMA-IR (1.04 ± 0.14 vs
2.48 ± 0.18; P < 0.011) as well as HOMA-B were found
lower in GDM having BMI < 23 kg/m2 than those of
GDM with BMI ≥ 23. Conversely, HOMA-%S (115.52 ±
14.63 vs 50.62 ± 3.39; P < 0.011) was higher in the
subgroup with BMI < 23 than the rest. Fasting blood
glucose (FBG) (P < 0.01) and fasting insulin (P < 0.05)
were independent predictors for GDM.

Conclusions. Fasting C-peptide did not differ between
GDM and NGT. BMI was positively related with resistance
and secretion of insulin but inversely with sensitivity.
HOMA model analyses revealed decreased insulin
sensitivity and secretory capacity in GDM than NGT.

Get Citation

Keywords

GDM, Insulin, C-peptide, HOMA IR, HOMA B & HOMA-%S

About this article
Title

Body mass index correlates positively with insulin resistance and secretion but inversely with insulin sensitivity in gestational diabetes

Journal

Clinical Diabetology

Issue

Vol 10, No 3 (2021)

Article type

Research paper

Pages

270-275

Published online

2021-03-03

DOI

10.5603/DK.a2021.0019

Bibliographic record

Clinical Diabetology 2021;10(3):270-275.

Keywords

GDM
Insulin
C-peptide
HOMA IR
HOMA B & HOMA-%S

Authors

Tania Tofail
Sharmin Jahan
Mashfiqul Hasan
Fakhrul Alam
Mohammad Fariduddin
Ahmed Abu Saleh
Muhammad Abul Hasanat

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