Vol 10, No 3 (2021)
Research paper
Published online: 2021-02-16

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The effect of intermittent fasting on mortality in patients with type 2 diabetes and metabolic disease with high cardiovascular risk: a systematic review

Lolita Matiashova1, Aparajeya Shanker2, Ganna Isayeva1
Clin Diabetol 2021;10(3):284-289.


Background. Intermittent fasting (IF) is a modern
method of modifying eating behavior in patients
who cannot tolerate calorie restriction. Intermittent
fasting is effective in weight loss and has different
types, which allows patients to adopt the type they
are most comfortable with. Intermittent fasting has
positive effects on human health, and this can lead IF
to be adopted in standard medical care. There is insufficient
data on the effect of IF on mortality and health
status in patients with comorbid pathology. The aims
of this systematic review are to analyze and summarize
data from original studies about IF and mortality in
patients with type 2 diabetes, metabolic disease and
high cardiovascular risk.

Methods. Original studies published in the last 5 years
were selected from MEDLINE via PubMed, Web of
Science, Scopus and Google Scholar using PRISMA

Results. Twenty-nine original articles were selected and
analyzed. Intermittent fasting showed a statistically
significant reduction in BMI, LDL, TG, HDL and HbA1C.
Data from this systematic review shows that IF is
a safe and effective way of reducing BMI in patients
with co-morbidities.

Conclusion. Further long-term studies examining the
effects of IF on mortality in co-morbid patients are

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