Vol 10, No 3 (2021)
Review article
Published online: 2021-03-05

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The role of FOXO transcription factors in development of type 2 diabetes and potential therapeutic possibilities

Weronika Bielka1, Agnieszka Przezak1
Clin Diabetol 2021;10(3):290-298.


Forkhead box class O (FOXO) family member proteins
are key transcription factors for maintaining the intracellular
homeostasis in response to changes in the
internal and external environment. They participate in
the control of such cellular processes as proliferation,
cell cycle, apoptosis, glucose and lipid metabolism,
and oxidative stress response. Altered expression and
activity of these factors are associated with development
of metabolic disturbances, primarily type 2
diabetes. Understanding of the role of FOXO in the
pathophysiology of these abnormalities will enable
appropriate steps to prevent their development and to
create therapies targeted at the disturbances underlying
type 2 diabetes and metabolic syndrome. In the
present article, we summarized the current knowledge
about the physiology and pathophysiology of these
transcription factors and described their role in the
development of diabetes and functioning of various
organs. We focused on their role in progression of
diabetes and indicated potential targets for future
therapeutic interventions.

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