open access

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Research paper
Published online: 2021-03-05
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Type one diabetes and autoimmune-related conditions: a Portuguese research in pediatric age

Vanessa Oliveira Gorito, Miguel Bernardo, André Almeida, Cristina Cândido, Vânia Martins
DOI: 10.5603/DK.a2021.0031

open access

Ahead of print
Original articles (submitted)
Published online: 2021-03-05

Abstract

Background. Type 1 diabetes (T1D) is the most common chronic metabolic disease among children and the autoimmune process can induce the development of additional autoimmune diseases. We performed a retrospective study of the clinical records and analytical determinations of pediatric patients with T1D during a five-year-period.
Methods. We identify 102 patients, similar gender distribution. In 98% was performed, at least, one tracking of other autoimmune disease. We found positive autoantibodies in 31%: thyroid antibodies (n = 16), antibodies for celiac disease (n = 10), and antinuclear antibodies (n = 5). Antibodies positivity occurred in mean 3.6 years after T1D diagnosis. Other conditions associated were pulmonary hemosiderosis, vitiligo, IgA deficit, uveitis, and positive Anti-Saccharomyces cerevisiae antibodies.
Conclusions. Despite the antibodies’ positivity we highlight the possibility of other less common autoimmune-related conditions. The screening of comor-bidities is fundamental to perform an earlier diagnosis and prevent complications.

Abstract

Background. Type 1 diabetes (T1D) is the most common chronic metabolic disease among children and the autoimmune process can induce the development of additional autoimmune diseases. We performed a retrospective study of the clinical records and analytical determinations of pediatric patients with T1D during a five-year-period.
Methods. We identify 102 patients, similar gender distribution. In 98% was performed, at least, one tracking of other autoimmune disease. We found positive autoantibodies in 31%: thyroid antibodies (n = 16), antibodies for celiac disease (n = 10), and antinuclear antibodies (n = 5). Antibodies positivity occurred in mean 3.6 years after T1D diagnosis. Other conditions associated were pulmonary hemosiderosis, vitiligo, IgA deficit, uveitis, and positive Anti-Saccharomyces cerevisiae antibodies.
Conclusions. Despite the antibodies’ positivity we highlight the possibility of other less common autoimmune-related conditions. The screening of comor-bidities is fundamental to perform an earlier diagnosis and prevent complications.

Get Citation

Keywords

type 1 diabetes; autoimmune conditions; tracking comorbidities; antibodies determination

About this article
Title

Type one diabetes and autoimmune-related conditions: a Portuguese research in pediatric age

Journal

Clinical Diabetology

Issue

Ahead of print

Article type

Research paper

Published online

2021-03-05

DOI

10.5603/DK.a2021.0031

Keywords

type 1 diabetes
autoimmune conditions
tracking comorbidities
antibodies determination

Authors

Vanessa Oliveira Gorito
Miguel Bernardo
André Almeida
Cristina Cândido
Vânia Martins

References (7)
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