Vol 10, No 5 (2021)
Research paper
Published online: 2021-03-05

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Type one diabetes and autoimmune-related conditions: a Portuguese research in pediatric age

Vanessa Oliveira Gorito1, Miguel Bernardo2, André Almeida2, Cristina Cândido2, Vânia Martins2
Clin Diabetol 2021;10(5):386-388.


Background. Type 1 diabetes (T1D) is the most common chronic metabolic disease among children and the autoimmune process can induce the development of additional autoimmune diseases. We performed a retrospective study of the clinical records and analytical determinations of pediatric patients with T1D during a five-year-period.
Methods. We identify 102 patients, similar gender distribution. In 98% was performed, at least, one tracking of other autoimmune disease. We found positive autoantibodies in 31%: thyroid antibodies (n = 16), antibodies for celiac disease (n = 10), and antinuclear antibodies (n = 5). Antibodies positivity occurred in mean 3.6 years after T1D diagnosis. Other conditions associated were pulmonary hemosiderosis, vitiligo, IgA deficit, uveitis, and positive Anti-Saccharomyces cerevisiae antibodies.
Conclusions. Despite the antibodies’ positivity we highlight the possibility of other less common autoimmune-related conditions. The screening of comor-bidities is fundamental to perform an earlier diagnosis and prevent complications.

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