Serum Adenosine Deaminase and C - reactive protein in Diabetic patients with and without Neuropathy
Abstract
Background: Diabetic Peripheral Neuropathy (DPN) is one major microvascular complication of long-standing diabetes mellitus with a prevalence of 50-60%. DPN leads to decreased quality of life, increased morbidity, and mortality. C reactive protein (CRP) and Adenosine deaminase (ADA) are independent inflammatory markers; the current study aims to evaluate and compare serum ADA, CRP in diabetic patients with and without neuropathy. Materials and Methods: A prospective study was done on 160 diabetic patients with and without neuropathy who visited the Medicine department of Kasturba hospital Manipal. Patients grouped into two, diabetic with neuropathy (n=80) and without Neuropathy (n=80). Serum samples were collected and analysed for CRP and ADA. Results: The data were analyzed using the Independent t-test and Mann-Whitney U test. There was a significantly high level of ADA (p=0.032) in neuropathy patients when compared with the non-DPN group. No significant difference was seen in CRP levels (p=0.123) in DPN patients compared to non-DPN patients. Conclusion: Monitoring of inflammatory markers like ADA in diabetic patients can provide insight into preventing DPN and its associated complications.
Keywords: Diabetes MellitusDiabetic peripheral NeuropathyC - reactive proteinAdenosine Deaminase.
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