open access

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Research paper
Published online: 2021-03-05
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Autoantibodies in Moroccan patients with type 1 diabetes: Which one to choose?

Faycal El Guendouz, Sara Derrou, Yousra Benabdelfedil, Hassan Ouleghzal, Somaya Safi
DOI: 10.5603/DK.a2021.0030

open access

Ahead of print
ORIGINAL ARTICLES
Published online: 2021-03-05

Abstract

Background. Immunological investigations are intend-ed for diagnosing T1D in atypical clinical presentation, also exploring the predisposition to T1D in a context of multiple autoimmune disorders or among the siblings of a patient with type 1 diabetes. While the diagnosing or the screening of T1D using five antibodies presents high expenses especially in emerging countries, it is for interest to determine their prevalence in order to choose the most frequent and most relevant. The aim of our study is to determine the prevalence of antibodies in Moroccan population.
Methods. We investigated 62 T1D patients, the prevalence of autoantibodies was 74% for glutamic acid decarboxylase 65 autoantibody (GADA), 46% for insulinoma-associated protein 2 autoantibody (IA2A), and 3% for islet cell antibodies (ICA). GADA and/or IA2A were reported in all patients (100%). The GADA frequency was neither associated with the duration of diabetes nor the age of patients.
Results. Finally, GADAs are by far the best markers for T1D, IA2As complements GADAs and increases the diagnostic sensitivity for detection of pancreatic autoimmunity and ICA should be abandoned because of its low prevalence.

Abstract

Background. Immunological investigations are intend-ed for diagnosing T1D in atypical clinical presentation, also exploring the predisposition to T1D in a context of multiple autoimmune disorders or among the siblings of a patient with type 1 diabetes. While the diagnosing or the screening of T1D using five antibodies presents high expenses especially in emerging countries, it is for interest to determine their prevalence in order to choose the most frequent and most relevant. The aim of our study is to determine the prevalence of antibodies in Moroccan population.
Methods. We investigated 62 T1D patients, the prevalence of autoantibodies was 74% for glutamic acid decarboxylase 65 autoantibody (GADA), 46% for insulinoma-associated protein 2 autoantibody (IA2A), and 3% for islet cell antibodies (ICA). GADA and/or IA2A were reported in all patients (100%). The GADA frequency was neither associated with the duration of diabetes nor the age of patients.
Results. Finally, GADAs are by far the best markers for T1D, IA2As complements GADAs and increases the diagnostic sensitivity for detection of pancreatic autoimmunity and ICA should be abandoned because of its low prevalence.

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Keywords

type 1 diabetes; pancreatic autoimmunity; pancreatic autoantibodies; GADA; IA2A; ICA

About this article
Title

Autoantibodies in Moroccan patients with type 1 diabetes: Which one to choose?

Journal

Clinical Diabetology

Issue

Ahead of print

Article type

Research paper

Published online

2021-03-05

DOI

10.5603/DK.a2021.0030

Keywords

type 1 diabetes
pancreatic autoimmunity
pancreatic autoantibodies
GADA
IA2A
ICA

Authors

Faycal El Guendouz
Sara Derrou
Yousra Benabdelfedil
Hassan Ouleghzal
Somaya Safi

References (10)
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