Vol 9, No 6 (2020)
Research paper
Published online: 2020-09-30

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Plasma microRNA-192 expression as a potential biomarker of diabetic kidney disease in patients with type 2 diabetes mellitus

Talaat Abd El Fattah Abdelaty1, Eman Yousef Morsy1, Eman Tayae El-Sayed1, Shimaa Mohamed El-Rahmany1, Sameh Aldesoky Anwar Lashen1
Clin Diabetol 2020;9(6):454-460.


Background. Albuminuria is an early clinical indicator of diabetic kidney disease (DKD). However, it has several limitations. The aim of this study was to evaluate the plasma microRNA-192 (miRNA-192) expression and its diagnostic performance in patients with type 2 diabetes mellitus (T2DM) and DKD.
Methods. In this case-control study, 75 subjects were included into 3 groups: group (1): 20 patients with T2DM and UACR (urinary albumin creatinine ratio) < 30 mg/gm, group (2): 30 patients with T2DM and ACR ≥ 30 mg/gm, and group (3): 25 healthy controls. Patients were recruited from the outpatient clinic of the Diabetes unit at our institution. Real-Time Quantitative Reverse Transcription PCR was used to assess plasma miRNA-192 expression.
Results. Plasma miRNA-192 was significantly higher in T2DM patients with DKD compared to those with normal UAE. Additionally, in patients with T2DM, plasma miRNA-192 was positively correlated with UACR. The ROC curve analysis for miRNA-192 plasma expression in patients with T2DM, revealed that miRNA-192 had a good diagnostic performance (AUC = 0.778) to define T2DM patients with DKD.
Conclusion. Plasma expression of miRNA-192 was able to discriminate increased UAE among patients with T2DM; suggesting a promising role for miRNA-192 as a potential biomarker for DKD.

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