Vol 9, No 2 (2020)
Research paper
Published online: 2020-02-10

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Sugary beverages consumption and latent autoimmune diabetes in adults: systematic review and meta-analysis

Ahmed Mahmoud El-Malky12, Ramachandra G Naik3, Azza A Elnouman4
Clin Diabetol 2020;9(2):118-127.


Introduction. Sugary beverages consumption (SBC) has amplified globally. SBC is associated with and leads to obesity and chronic diseases, nonetheless the role of SBC in development of autoimmune disorders such as latent autoimmune diabetes in adults (LADA) has not been addressed adequately among the different ethnic groups. We conducted this meta-analysis to compare the random effect of SBC intake on the risk of development of LADA.

Methods. We scrutinized the MEDLINE database up until January 2019 for articles addressing the associa­tion between sugary beverages, coffee consumption and LADA. We found 6 studies all of them addressed the LADA. We have included them in the meta-analysis and compared the random effect of SBC from the uppermost to the lowermost quantiles parallel to the risk of LADA.

Results. According to the research conducted, and data extracted, which involved 15027 contributors and 1862 patients with LADA, the participants in the uppermost quantile of SBC intake (used 1–2 servings per day in most cases) were at risk of developing LADA more than those in the lowermost quantile (≤ 1 serving per month) (odds ratio [OR] 1.37 [95% CI 1.23–1.52]).

Conclusion. According to the meta-analysis results excessive SBC intake may increase the risk of develop­ment of latent autoimmune diabetes in adults. However, no definite conclusions could be drawn due to heterogeneous data from low quality researches and the analysis was based on observational and case-control studies only.

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