Vol 6, No 6 (2017)
Case report
Published online: 2018-01-26

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Sitagliptin induced splenic infarcts

Raiz Ahmad Misgar1, Javaid Ahmad Bhat2, Arshad Iqbal Wani1, Mir Iftikhar Bashir1
Clin Diabetol 2017;6(6):215-217.


  Sitagliptin belongs to the class of dipeptidyl pepti­dase-4 (DPP-4) inhibitors. DPP-4 inhibitors are remark­ably well tolerated oral antihyperglycemic drugs with an adverse effect profile similar to that of placebo. No adverse effects have been reported even with overdose of sitagliptin in suicide attempts. We present here case summary of a 35-year-old female with type 2 diabetes mellitus and major depressive disorder who presented with multiple splenic infarcts after ingestion of sitag­liptin 700 mg and metformin 14 g with suicidal intent. To the best of our knowledge, there are no published reports of splenic infarcts as an adverse event of sit­agliptin. (Clin Diabetol 2017; 6, 6: 215–217)

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