open access

Vol 6, No 3 (2017)
CASE REPORT
Published online: 2017-09-29
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New-onset hyperglycemia: A potential clue to detect early pancreatic cancer

Partha Pratim Chakraborty, Sayantan Ray, Satinath Mukhopadhyay, Subhankar Chowdhury
DOI: 10.5603/DK.2017.0019
·
Clinical Diabetology 2017;6(3):115-117.

open access

Vol 6, No 3 (2017)
CASE REPORT
Published online: 2017-09-29

Abstract

Pancreatic adenocarcinoma has an incidence rate nearly equal to the mortality rate and this is mostly due to late symptom onset and diagnosis. Evidence has indicated that new-onset diabetes may be a manifestation of occult pancreatic carcinoma. Authors report the case of a young female who presented with new-onset severe hyperglycemia and superficial thrombophlebitis. She was subsequently diagnosed with pancreatic cancer confirmed by histopathology. Her glycemic status evaluated 6 months prior to her presentation during institutional health check-up was entirely normal. This case report will serve to emphasize that new-onset diabetes in certain patients could be a presenting feature of pancreatic cancer.

Abstract

Pancreatic adenocarcinoma has an incidence rate nearly equal to the mortality rate and this is mostly due to late symptom onset and diagnosis. Evidence has indicated that new-onset diabetes may be a manifestation of occult pancreatic carcinoma. Authors report the case of a young female who presented with new-onset severe hyperglycemia and superficial thrombophlebitis. She was subsequently diagnosed with pancreatic cancer confirmed by histopathology. Her glycemic status evaluated 6 months prior to her presentation during institutional health check-up was entirely normal. This case report will serve to emphasize that new-onset diabetes in certain patients could be a presenting feature of pancreatic cancer.

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Keywords

pancreatic carcinoma, new-onset hyperglycemia, warning sign, asymptomatic stage

About this article
Title

New-onset hyperglycemia: A potential clue to detect early pancreatic cancer

Journal

Clinical Diabetology

Issue

Vol 6, No 3 (2017)

Pages

115-117

Published online

2017-09-29

DOI

10.5603/DK.2017.0019

Bibliographic record

Clinical Diabetology 2017;6(3):115-117.

Keywords

pancreatic carcinoma
new-onset hyperglycemia
warning sign
asymptomatic stage

Authors

Partha Pratim Chakraborty
Sayantan Ray
Satinath Mukhopadhyay
Subhankar Chowdhury

References (10)
  1. Pannala R, Basu A, Petersen GM, et al. New-onset diabetes: a potential clue to the early diagnosis of pancreatic cancer. Lancet Oncol. 2009; 10(1): 88–95.
  2. Gupta S, Vittinghoff E, Bertenthal D, et al. New-onset diabetes and pancreatic cancer. Clin Gastroenterol Hepatol. 2006; 4(11): 1366–72; quiz 1301.
  3. Sah RP, Nagpal SJ, Mukhopadhyay D, et al. New insights into pancreatic cancer-induced paraneoplastic diabetes. Nat Rev Gastroenterol Hepatol. 2013; 10(7): 423–433.
  4. Pannala R, Leirness JB, Bamlet WR, et al. Prevalence and clinical profile of pancreatic cancer-associated diabetes mellitus. Gastroenterology. 2008; 134(4): 981–987.
  5. Patel R, Ede J, Collins J, et al. Pancreatic cancer presenting as new-onset diabetes. Case Rep Oncol. 2014; 7(1): 171–174.
  6. Everhart J, Wright D. Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis. JAMA. 1995; 273(20): 1605–1609.
  7. Permert J, Ihse I, Jorfeldt L, et al. Pancreatic cancer is associated with impaired glucose metabolism. Eur J Surg. 1993; 159(2): 101–107.
  8. Gangi S, Fletcher JG, Nathan MA, et al. Time interval between abnormalities seen on CT and the clinical diagnosis of pancreatic cancer: retrospective review of CT scans obtained before diagnosis. AJR Am J Roentgenol. 2004; 182(4): 897–903.
  9. Guo Q, Kang M, Zhang Bo, et al. Elevated levels of CA 19-9 and CEA in pancreatic cancer-associated diabetes. J Cancer Res Clin Oncol. 2010; 136(11): 1627–1631.
  10. Aggarwal G, Ramachandran V, Javeed N, et al. Adrenomedullin is up-regulated in patients with pancreatic cancer and causes insulin resistance in β cells and mice. Gastroenterology. 2012; 143(6): 1510–1517.e1.

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