open access

Vol 6, No 2 (2017)
Original articles (submitted)
Published online: 2017-08-04
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Glucose variability and glycated hemoglobin HbA1c in type 1 and type 2 diabetes

Anna Borkowska, Elektra Szymańska-Garbacz, Ewa Kwiecińska, Anna Ignaczak, Leszek Czupryniak
DOI: 10.5603/DK.2017.0009
·
Clinical Diabetology 2017;6(2):48-56.

open access

Vol 6, No 2 (2017)
Original articles (submitted)
Published online: 2017-08-04

Abstract

Introduction. The ultimate goal of diabetes therapy is to prevent chronic complications of the disease. HbA1c level is closely related to the risk of development of micro- and macrovascular complications, however blood glucose variability (BGV) has emerged recently as yet another possible risk factor for vascular, particularly endothelial damage in diabetes. Continuous glucose monitoring systems (CGMS) are currently used for the BGV assessment, however due to their costs they are rarely utilised in daily clinical practice. The aim of the study was to assess BGV and its relationship with HbA1c in patients with well (HbA1c ∼7%) and poorly (HbA1c ∼10%) controlled type 1 and type 2 diabetes.

Material and methods. 131 patients subdivided in 4 groups according to diabetes type and level of metabolic control were enrolled into the study. All patients underwent continuous glucose monitoring with the use of iPRO2 system (Medtronic).

Results. BGV was lower in type 2 than in type 1 diabetes patients. There was no statistically significant relationship between BGV and HbA1c in well or poorly controlled patients with type 1 or type 2 diabetes. However, well controlled type 1 diabetes patients presented with greater degree of BGV than poorly controlled type 1 diabetes subjects.

Conclusions. HbA1c does not reflect blood glucose variability as assessed with CGMS in type 1 or type 2 diabetes subjects. BGV is significantly greater in type 1 diabetes than in type 2 diabetes, therefore the use CGMS might be of particular benefit for the former group of patients, especially those with good glycemic control.

Abstract

Introduction. The ultimate goal of diabetes therapy is to prevent chronic complications of the disease. HbA1c level is closely related to the risk of development of micro- and macrovascular complications, however blood glucose variability (BGV) has emerged recently as yet another possible risk factor for vascular, particularly endothelial damage in diabetes. Continuous glucose monitoring systems (CGMS) are currently used for the BGV assessment, however due to their costs they are rarely utilised in daily clinical practice. The aim of the study was to assess BGV and its relationship with HbA1c in patients with well (HbA1c ∼7%) and poorly (HbA1c ∼10%) controlled type 1 and type 2 diabetes.

Material and methods. 131 patients subdivided in 4 groups according to diabetes type and level of metabolic control were enrolled into the study. All patients underwent continuous glucose monitoring with the use of iPRO2 system (Medtronic).

Results. BGV was lower in type 2 than in type 1 diabetes patients. There was no statistically significant relationship between BGV and HbA1c in well or poorly controlled patients with type 1 or type 2 diabetes. However, well controlled type 1 diabetes patients presented with greater degree of BGV than poorly controlled type 1 diabetes subjects.

Conclusions. HbA1c does not reflect blood glucose variability as assessed with CGMS in type 1 or type 2 diabetes subjects. BGV is significantly greater in type 1 diabetes than in type 2 diabetes, therefore the use CGMS might be of particular benefit for the former group of patients, especially those with good glycemic control.

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Keywords

glycaemic variability, continuous glucose monitoring system, glycated haemoglobin HbA1c

About this article
Title

Glucose variability and glycated hemoglobin HbA1c in type 1 and type 2 diabetes

Journal

Clinical Diabetology

Issue

Vol 6, No 2 (2017)

Pages

48-56

Published online

2017-08-04

DOI

10.5603/DK.2017.0009

Bibliographic record

Clinical Diabetology 2017;6(2):48-56.

Keywords

glycaemic variability
continuous glucose monitoring system
glycated haemoglobin HbA1c

Authors

Anna Borkowska
Elektra Szymańska-Garbacz
Ewa Kwiecińska
Anna Ignaczak
Leszek Czupryniak

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