open access

Vol 5, No 4 (2016)
Review
Published online: 2016-11-03
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Metformin — today’s panacea?

Magdalena Potempa, Paweł Jonczyk, Kinga Szczerba, Beata Kandefer, Dariusz Kajdaniuk
DOI: 10.5603/DK.2016.0020
·
Clinical Diabetology 2016;5(4):117-122.

open access

Vol 5, No 4 (2016)
Review
Published online: 2016-11-03

Abstract

Metformin is still an immutable basic hypoglycemic drug used in pharmacotherapy of diabetes mellitus type 2. Structurally it belongs to biguanide derivatives that was discovered in traditional herbalism. Galega officinalis was a plant used to obtain substances similar to metformin. This drug can induce a state in a cell, which occurs as a result of caloric restriction. It consists in decreasing the effectiveness of IGF-1 metabolic pathway with the insulin-like growth factor 1 and mTOR kinase activity, thus metformin contributes to extend a lifespan among animals. This article presents a brief overview of studies about anti-aging potential of metformin. Beside this, the authors have described caloric restriction role taking part in a lifespan as well as slowing down incidence of age related diseases.

Abstract

Metformin is still an immutable basic hypoglycemic drug used in pharmacotherapy of diabetes mellitus type 2. Structurally it belongs to biguanide derivatives that was discovered in traditional herbalism. Galega officinalis was a plant used to obtain substances similar to metformin. This drug can induce a state in a cell, which occurs as a result of caloric restriction. It consists in decreasing the effectiveness of IGF-1 metabolic pathway with the insulin-like growth factor 1 and mTOR kinase activity, thus metformin contributes to extend a lifespan among animals. This article presents a brief overview of studies about anti-aging potential of metformin. Beside this, the authors have described caloric restriction role taking part in a lifespan as well as slowing down incidence of age related diseases.

Get Citation

Keywords

metformin, aging, mTOR kinase, IGF-1 pathway, studies

About this article
Title

Metformin — today’s panacea?

Journal

Clinical Diabetology

Issue

Vol 5, No 4 (2016)

Pages

117-122

Published online

2016-11-03

DOI

10.5603/DK.2016.0020

Bibliographic record

Clinical Diabetology 2016;5(4):117-122.

Keywords

metformin
aging
mTOR kinase
IGF-1 pathway
studies

Authors

Magdalena Potempa
Paweł Jonczyk
Kinga Szczerba
Beata Kandefer
Dariusz Kajdaniuk

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