open access

Vol 4, No 1 (2015)
Original articles (submitted)
Published online: 2015-05-11
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Early markers of atherosclerosis in patients with impaired fasting glucose.

Małgorzata Jadwiga Saryusz-Wolska, Michał Podgórski, Jolanta Barbara Jurczyńska, Elektra Szymańska-Garbacz, Piotr Grzelak, Ludomir Stefańczyk, Jerzy Maksymilian Loba
DOI: 10.5603/DK.2015.0001
·
Diabetologia Kliniczna 2015;4(1):3-8.

open access

Vol 4, No 1 (2015)
Original articles (submitted)
Published online: 2015-05-11

Abstract

Introduction. It is known that increased plasma glucose, which includes impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes, is a risk factor for atherosclerosis. Individuals with IFG exhibit a higher rate of cardiovascular events compared with those with normal fasting glucose. The aim of the study was to evaluate whether IFG has an influence on early markers of atherosclerosis [intima media thickness (IMT), strain (S, deformation of the vessels wall), and strain rate (Sr, deformation over time)] in common ca­rotid artery (CCA) compare to healthy subjects (without disturbances of glucose metabolism).

Patients and methods. A group of 25 dysglycemic patients with IFG and 15 healthy subjects of similar age and gender were examined. Blood analyses and anthropometric measurement [systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR)] were obtained. Carotid IMT, S, and Sr were measured by tissue Doppler. IFP was diagnosed according to the diagnostic criteria for IFG in Poland.

Results. Patients with IFG had higher DBP and IMT of CCA (right and left) compared with control. There was no difference in SBP and HR between patients with IFG and controls. Strain of CCA was decreased in subject with IFG compared with controls and strain rate of CCA was increased in patients with IFG compared with the controls.

Conclusion. IFG may have an influence on early markers of atherosclerosis, but further investigations are needed to confirm these observations.

Abstract

Introduction. It is known that increased plasma glucose, which includes impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes, is a risk factor for atherosclerosis. Individuals with IFG exhibit a higher rate of cardiovascular events compared with those with normal fasting glucose. The aim of the study was to evaluate whether IFG has an influence on early markers of atherosclerosis [intima media thickness (IMT), strain (S, deformation of the vessels wall), and strain rate (Sr, deformation over time)] in common ca­rotid artery (CCA) compare to healthy subjects (without disturbances of glucose metabolism).

Patients and methods. A group of 25 dysglycemic patients with IFG and 15 healthy subjects of similar age and gender were examined. Blood analyses and anthropometric measurement [systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR)] were obtained. Carotid IMT, S, and Sr were measured by tissue Doppler. IFP was diagnosed according to the diagnostic criteria for IFG in Poland.

Results. Patients with IFG had higher DBP and IMT of CCA (right and left) compared with control. There was no difference in SBP and HR between patients with IFG and controls. Strain of CCA was decreased in subject with IFG compared with controls and strain rate of CCA was increased in patients with IFG compared with the controls.

Conclusion. IFG may have an influence on early markers of atherosclerosis, but further investigations are needed to confirm these observations.

Get Citation

Keywords

atherosclerosis, prediabetes, impaired fasting glucose, intima media thickness

About this article
Title

Early markers of atherosclerosis in patients with impaired fasting glucose.

Journal

Clinical Diabetology

Issue

Vol 4, No 1 (2015)

Pages

3-8

Published online

2015-05-11

DOI

10.5603/DK.2015.0001

Bibliographic record

Diabetologia Kliniczna 2015;4(1):3-8.

Keywords

atherosclerosis
prediabetes
impaired fasting glucose
intima media thickness

Authors

Małgorzata Jadwiga Saryusz-Wolska
Michał Podgórski
Jolanta Barbara Jurczyńska
Elektra Szymańska-Garbacz
Piotr Grzelak
Ludomir Stefańczyk
Jerzy Maksymilian Loba

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