open access

Vol 4, No 1 (2015)
Review
Published online: 2015-05-11
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Diabetes in the 24/7 society. The relationship between shift work and metabolic disorders

Wojciech Wołyniec, Michał Kurlapski, Jacek Januszczyk, Marcin Renke
DOI: 10.5603/DK.2015.0004
·
Diabetologia Kliniczna 2015;4(1):22-28.

open access

Vol 4, No 1 (2015)
Review
Published online: 2015-05-11

Abstract

In the contemporary world with the high pace of life and industrialization, more and more people are getting employed on the shift work basis. So far a lot of investigations have indicated harmfulness of this kind of work, treating it as a risk factor for many diseases and medical problems i.e. sleep disorders, peptic ulcer, cancer, obesity, diabetes, dyslipidemias, high blood pressure and coronary heart disease. Biological clock plays a crucial role on physiological processes starting with heart rate and blood pressure along with complex metabolic processes. Regulation of this mechanisms takes place on few levels: neurological (central biological clock), hormonal (melatonin) and molecular (pre, cry, clock and bal1 genes transcription). External time givers (Zeitgebers) such as sunlight, moving, eating or temperature can modulate these processes. Shift work results in increase risk of metabolic syndrome, cognitive function worsening, immunodeficiency, hormones disturbances or even death or suicide from over-strain. This review summarizes uptodated knowledge on links between shift work and the risk of obesity, hormones disturbances and type 2 diabetes.

Abstract

In the contemporary world with the high pace of life and industrialization, more and more people are getting employed on the shift work basis. So far a lot of investigations have indicated harmfulness of this kind of work, treating it as a risk factor for many diseases and medical problems i.e. sleep disorders, peptic ulcer, cancer, obesity, diabetes, dyslipidemias, high blood pressure and coronary heart disease. Biological clock plays a crucial role on physiological processes starting with heart rate and blood pressure along with complex metabolic processes. Regulation of this mechanisms takes place on few levels: neurological (central biological clock), hormonal (melatonin) and molecular (pre, cry, clock and bal1 genes transcription). External time givers (Zeitgebers) such as sunlight, moving, eating or temperature can modulate these processes. Shift work results in increase risk of metabolic syndrome, cognitive function worsening, immunodeficiency, hormones disturbances or even death or suicide from over-strain. This review summarizes uptodated knowledge on links between shift work and the risk of obesity, hormones disturbances and type 2 diabetes.

Get Citation

Keywords

diabetes mellitus, shift work, metabolic syndrome, biological clock, Zeitgebers, CLOCK protein

About this article
Title

Diabetes in the 24/7 society. The relationship between shift work and metabolic disorders

Journal

Clinical Diabetology

Issue

Vol 4, No 1 (2015)

Pages

22-28

Published online

2015-05-11

DOI

10.5603/DK.2015.0004

Bibliographic record

Diabetologia Kliniczna 2015;4(1):22-28.

Keywords

diabetes mellitus
shift work
metabolic syndrome
biological clock
Zeitgebers
CLOCK protein

Authors

Wojciech Wołyniec
Michał Kurlapski
Jacek Januszczyk
Marcin Renke

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