open access

Vol 29, No 4 (2022)
Study Protocol
Submitted: 2021-12-16
Accepted: 2022-03-16
Published online: 2022-04-19
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Trimethylamine-N-oxide (TMAO) versus echocardiographic, biochemical and histopathological indices of heart failure in patients with severe aortic stenosis: Rationale and design of the prospective, observational TASTE study

Aleksandra Gąsecka12, Łukasz Rzepa1, Michał Konwerski1, Magdalena Zawadzka1, Karol Wysocki1, Monika Budnik1, Paweł Czub3, Radosław Wilimski3, Mateusz Wondołkowski3, Joanna Wilczyńska-Burlikowska1, Piotr Scisło1, Marek Konop4, Zenon Huczek1, Janusz Kochman1, Janusz Kochanowski1, Grzegorz Opolski1, Krzysztof J. Filipiak5, Marcin Ufnal4, Agnieszka Kapłon-Cieślicka1
DOI: 10.5603/CJ.a2022.0023
·
Pubmed: 35470417
·
Cardiol J 2022;29(4):691-697.
Affiliations
  1. 1st Chair and Department of Cardiology, Medical University of Warsaw, Poland
  2. Laboratory of Experimental Clinical Chemistry, Academic Medical Center, Amsterdam University Medical Centers, The Netherlands
  3. Department of Cardiac Surgery, Medical University of Warsaw, Poland
  4. Department of Experimental Physiology and Pathophysiology, Laboratory of Center for Preclinical Research, Medical University of Warsaw, Poland
  5. Department of Clinical Sciences, Maria Sklodowska-Curie Medical Academy, Warsaw, Poland

open access

Vol 29, No 4 (2022)
Study protocol — Clinical cardiology
Submitted: 2021-12-16
Accepted: 2022-03-16
Published online: 2022-04-19

Abstract

Not available

Abstract

Not available
Get Citation

Keywords

aortic stenosis, trimethylamine N-oxide, trimethylamine, metalloproteinase, galectin-3, indoxyl sulphate

About this article
Title

Trimethylamine-N-oxide (TMAO) versus echocardiographic, biochemical and histopathological indices of heart failure in patients with severe aortic stenosis: Rationale and design of the prospective, observational TASTE study

Journal

Cardiology Journal

Issue

Vol 29, No 4 (2022)

Article type

Study Protocol

Pages

691-697

Published online

2022-04-19

Page views

1805

Article views/downloads

427

DOI

10.5603/CJ.a2022.0023

Pubmed

35470417

Bibliographic record

Cardiol J 2022;29(4):691-697.

Keywords

aortic stenosis
trimethylamine N-oxide
trimethylamine
metalloproteinase
galectin-3
indoxyl sulphate

Authors

Aleksandra Gąsecka
Łukasz Rzepa
Michał Konwerski
Magdalena Zawadzka
Karol Wysocki
Monika Budnik
Paweł Czub
Radosław Wilimski
Mateusz Wondołkowski
Joanna Wilczyńska-Burlikowska
Piotr Scisło
Marek Konop
Zenon Huczek
Janusz Kochman
Janusz Kochanowski
Grzegorz Opolski
Krzysztof J. Filipiak
Marcin Ufnal
Agnieszka Kapłon-Cieślicka

References (30)
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  14. Kayama S, Aratake S, Sawamura S, et al. Medium and long-term prognosis of transcatheter aortic valve implantation from the perspective of left ventricular diastolic function. Cardiol J. 2019; 26(1): 29–35.
  15. Bjørnstad JL, Neverdal NO, Vengen OA, et al. Alterations in circulating activin A, GDF-15, TGF-beta3 and MMP-2, -3, and -9 during one year of left ventricular reverse remodelling in patients operated for severe aortic stenosis. Eur J Heart Fail. 2008; 10(12): 1201–1207.
  16. Kupari M, Laine M, Turto H, et al. Circulating collagen metabolites, myocardial fibrosis and heart failure in aortic valve stenosis. J Heart Valve Dis. 2013; 22(2): 166–176.
  17. Zhong X, Qian X, Chen G, et al. The role of galectin-3 in heart failure and cardiovascular disease. Clin Exp Pharmacol Physiol. 2019; 46(3): 197–203.
  18. Fu Q, Cao L, Li H, et al. Cardiorenal syndrome: pathophysiological mechanism, preclinical models, novel contributors and potential therapies. Chin Med J (Engl). 2014; 127(16): 3011–3018.
  19. Lekawanvijit S, Kompa AR, Manabe M, et al. Chronic kidney disease-induced cardiac fibrosis is ameliorated by reducing circulating levels of a non-dialysable uremic toxin, indoxyl sulfate. PLoS One. 2012; 7(7): e41281.
  20. Organ CL, Otsuka H, Bhushan S, et al. Choline diet and its gut microbe-derived metabolite, trimethylamine N-oxide, exacerbate pressure overload-induced heart failure. Circ Heart Fail. 2016; 9(1): e002314.
  21. Ufnal M, Jazwiec R, Dadlez M, et al. Trimethylamine-N-oxide: a carnitine-derived metabolite that prolongs the hypertensive effect of angiotensin II in rats. Can J Cardiol. 2014; 30(12): 1700–1705.
  22. Jaworska K, Hering D, Mosieniak G, et al. TMA, A Forgotten Uremic Toxin, but Not TMAO, Is Involved in Cardiovascular Pathology. Toxins (Basel). 2019; 11(9).
  23. Jaworska K, Huc T, Samborowska E, et al. Hypertension in rats is associated with an increased permeability of the colon to TMA, a gut bacteria metabolite. PLoS One. 2017; 12(12): e0189310.
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  26. Konopelski P, Ufnal M. Indoles: gut bacteria metabolites of tryptophan with pharmacotherapeutic potential. Curr Drug Metab. 2018; 19(10): 883–890.
  27. Lekawanvijit S, Krum H. Cardiorenal syndrome: acute kidney injury secondary to cardiovascular disease and role of protein-bound uraemic toxins. J Physiol. 2014; 592(18): 3969–3983.
  28. Reuillard A, Garrouste C, Pereira B, et al. Evolution of chronic kidney disease after surgical aortic valve replacement or transcatheter aortic valve implantation. Arch Cardiovasc Dis. 2019; 112(3): 162–170.
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  30. Winther SA, Øllgaard JC, Tofte N, et al. Utility of plasma concentration of trimethylamine n-oxide in predicting cardiovascular and renal complications in individuals with type 1 diabetes. Diabetes Care. 2019; 42(8): 1512–1520.

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