open access

Ahead of print
Letter to the Editor
Published online: 2021-07-07
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Mortality reduction with levosimendan in patients with heart failure: Current evidence is underpowered

Filippo Sanfilippo, Luigi La Via, Federica Merola, Marinella Astuto
DOI: 10.5603/CJ.a2021.0078
·
Pubmed: 34240399

open access

Ahead of print
Letters to the Editor — Clinical cardiology
Published online: 2021-07-07

Abstract

Not available

Abstract

Not available
Get Citation

Keywords

dobutamine; meta-analysis; trial sequential analysis; ejection fraction

About this article
Title

Mortality reduction with levosimendan in patients with heart failure: Current evidence is underpowered

Journal

Cardiology Journal

Issue

Ahead of print

Article type

Letter to the Editor

Published online

2021-07-07

DOI

10.5603/CJ.a2021.0078

Pubmed

34240399

Keywords

dobutamine
meta-analysis
trial sequential analysis
ejection fraction

Authors

Filippo Sanfilippo
Luigi La Via
Federica Merola
Marinella Astuto

References (5)
  1. Jaguszewski MJ, Gasecka A, Targonski R, et al. Efficacy and safety of levosimendan and dobutamine in heart failure: A systematic review and meta-analysis. Cardiol J. 2021; 28(3): 492–493.
  2. Sanfilippo F, Knight JB, Scolletta S, et al. Levosimendan for patients with severely reduced left ventricular systolic function and/or low cardiac output syndrome undergoing cardiac surgery: a systematic review and meta-analysis. Crit Care. 2017; 21(1): 252.
  3. Afshari A, Wetterslev J. When may systematic reviews and meta-analyses be considered reliable? Eur J Anaesthesiol. 2015; 32(2): 85–87.
  4. Barili F, Parolari A, Kappetein PA, et al. Statistical Primer: heterogeneity, random- or fixed-effects model analyses? Interact Cardiovasc Thorac Surg. 2018; 27(3): 317–321.
  5. Mebazaa A, Nieminen MS, Packer M, et al. Levosimendan vs dobutamine for patients with acute decompensated heart failure: the SURVIVE Randomized Trial. JAMA. 2007; 297(17): 1883–1891.

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