open access

Vol 27, No 3 (2020)
Original articles — Clinical cardiology
Published online: 2018-08-31
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Association between mild thyroid dysfunction and clinical outcome in acute coronary syndrome undergoing percutaneous coronary intervention

Qian Cao, Yundi Jiao, Tongtong Yu, Zhaoqing Sun
DOI: 10.5603/CJ.a2018.0097
·
Pubmed: 30234907
·
Cardiol J 2020;27(3):262-271.

open access

Vol 27, No 3 (2020)
Original articles — Clinical cardiology
Published online: 2018-08-31

Abstract

Background: Thyroid hormones profoundly influence the cardiovascular system, but the effects of mild thyroid dysfunction on the clinical outcome of acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) are not well defined. This study aimed to determine the effect of mild thyroid dysfunction on 12-month prognosis in ACS patients undergoing PCI.

Methods: In this prospective cohort study with a 12-month follow-up, 1560 individuals were divided into four groups based on thyroid hormone levels upon admission: euthyroidism (used as a reference group), subclinical hypothyroidism, subclinical hyperthyroidism, and low triiodothyronine syndrome (low T3 syndrome). The outcomes measured were all-cause mortality, cardiac mortality, nonfatal rein­farction, and unplanned repeat revascularization.

Results: In this study, the prevalence of mild thyroid dysfunction was 10.8%. Multivariate analysis showed that low T3 syndrome, but not subclinical hypothyroidism or subclinical hyperthyroidism, was associated with a higher rate of all-cause (HR 2.553, 95% CI 1.093–5.964, p = 0.030) and cardiac mortality (HR 2.594, 95% CI 1.026–6.559, p = 0.034), compared with the euthyroidism group.

Conclusions: Mild thyroid dysfunction was frequent in patients with ACS undergoing PCI. Low T3 syndrome was the predominant feature and was associated with 12-month adverse outcomes in these patients.

Abstract

Background: Thyroid hormones profoundly influence the cardiovascular system, but the effects of mild thyroid dysfunction on the clinical outcome of acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) are not well defined. This study aimed to determine the effect of mild thyroid dysfunction on 12-month prognosis in ACS patients undergoing PCI.

Methods: In this prospective cohort study with a 12-month follow-up, 1560 individuals were divided into four groups based on thyroid hormone levels upon admission: euthyroidism (used as a reference group), subclinical hypothyroidism, subclinical hyperthyroidism, and low triiodothyronine syndrome (low T3 syndrome). The outcomes measured were all-cause mortality, cardiac mortality, nonfatal rein­farction, and unplanned repeat revascularization.

Results: In this study, the prevalence of mild thyroid dysfunction was 10.8%. Multivariate analysis showed that low T3 syndrome, but not subclinical hypothyroidism or subclinical hyperthyroidism, was associated with a higher rate of all-cause (HR 2.553, 95% CI 1.093–5.964, p = 0.030) and cardiac mortality (HR 2.594, 95% CI 1.026–6.559, p = 0.034), compared with the euthyroidism group.

Conclusions: Mild thyroid dysfunction was frequent in patients with ACS undergoing PCI. Low T3 syndrome was the predominant feature and was associated with 12-month adverse outcomes in these patients.

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Keywords

mild thyroid dysfunction, clinical outcome, acute coronary syndrome, percutaneous coronary intervention

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About this article
Title

Association between mild thyroid dysfunction and clinical outcome in acute coronary syndrome undergoing percutaneous coronary intervention

Journal

Cardiology Journal

Issue

Vol 27, No 3 (2020)

Pages

262-271

Published online

2018-08-31

DOI

10.5603/CJ.a2018.0097

Pubmed

30234907

Bibliographic record

Cardiol J 2020;27(3):262-271.

Keywords

mild thyroid dysfunction
clinical outcome
acute coronary syndrome
percutaneous coronary intervention

Authors

Qian Cao
Yundi Jiao
Tongtong Yu
Zhaoqing Sun

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