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Vol 24, No 5 (2017)
Original articles — Clinical cardiology
Published online: 2017-03-21
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The early variation of left ventricular twisting function in patients with lymphoma received anthracycline therapy assessed by three-dimensional speckle tracking echocardiography

Feiyan Song, Yu Kang, Chujie Zhang, Yuchen Xu, Jing Shi, Ye Guo, Qunling Zhang, Xianhong Shu, Leilei Cheng
DOI: 10.5603/CJ.a2017.0035
·
Pubmed: 28353310
·
Cardiol J 2017;24(5):484-494.

open access

Vol 24, No 5 (2017)
Original articles — Clinical cardiology
Published online: 2017-03-21

Abstract

Background: Anthracycline-induced cardiotoxicity remains a significant and unresolved issue in patients receiving chemotherapy. The aim of this study was to evaluate left ventricular (LV) twisting function by three-dimensional speckle tracking echocardiography (3D-STE) in patients with lymphoma after anthracycline therapy.

Methods: One hundred and one patients with newly diagnosed diffuse large B-cell lymphoma who had planned to receive anthracycline chemotherapy were enrolled. LV apical rotation, basal rotation, twist, torsion, time to peak apical rotation and time to peak basal rotation were measured by 3D-STE at baseline, after the completion of two cycles and four cycles of the regimen, respectively. Apical–basal rotation delay was calculated as the difference between time to basal and time to apical rotation.

Results: The results showed that LV apical rotation, basal rotation, twist and torsion declined progressively during the whole procedure (baseline vs. two and four cycles of the regimen, apical rotation: 12.5 ± ± 4.5° vs. 8.8 ± 3.6° vs. 6.0 ± 3.2°; basal rotation: –7.7 ± 3.0° vs. –5.9 ± 2.6° vs. –4.4 ± 2.5°; twist: 20.0 ± 6.4° vs. 14.5 ± 5.1° vs. 9.8 ± 4.5°; torsion: 2.9 ± 0.9°/cm vs. 2.1 ± 0.9°/cm vs. 1.4 ± 0.7°/cm; all p < 0.01). Furthermore, apical-basal rotation delay increased significantly after two cycles as well as after four cycles of the regimen (38.3 ± 67.9 ms vs. 66.7 ± 73.9 ms vs. 92.6 ± 96.9 ms; p < 0.01).

Conclusions: LV twisting function deteriorated in the early stage of anthracycline therapy in patients with lymphoma, which could be detected by 3D-STE sensitively.  

Abstract

Background: Anthracycline-induced cardiotoxicity remains a significant and unresolved issue in patients receiving chemotherapy. The aim of this study was to evaluate left ventricular (LV) twisting function by three-dimensional speckle tracking echocardiography (3D-STE) in patients with lymphoma after anthracycline therapy.

Methods: One hundred and one patients with newly diagnosed diffuse large B-cell lymphoma who had planned to receive anthracycline chemotherapy were enrolled. LV apical rotation, basal rotation, twist, torsion, time to peak apical rotation and time to peak basal rotation were measured by 3D-STE at baseline, after the completion of two cycles and four cycles of the regimen, respectively. Apical–basal rotation delay was calculated as the difference between time to basal and time to apical rotation.

Results: The results showed that LV apical rotation, basal rotation, twist and torsion declined progressively during the whole procedure (baseline vs. two and four cycles of the regimen, apical rotation: 12.5 ± ± 4.5° vs. 8.8 ± 3.6° vs. 6.0 ± 3.2°; basal rotation: –7.7 ± 3.0° vs. –5.9 ± 2.6° vs. –4.4 ± 2.5°; twist: 20.0 ± 6.4° vs. 14.5 ± 5.1° vs. 9.8 ± 4.5°; torsion: 2.9 ± 0.9°/cm vs. 2.1 ± 0.9°/cm vs. 1.4 ± 0.7°/cm; all p < 0.01). Furthermore, apical-basal rotation delay increased significantly after two cycles as well as after four cycles of the regimen (38.3 ± 67.9 ms vs. 66.7 ± 73.9 ms vs. 92.6 ± 96.9 ms; p < 0.01).

Conclusions: LV twisting function deteriorated in the early stage of anthracycline therapy in patients with lymphoma, which could be detected by 3D-STE sensitively.  

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Keywords

anthracycline, cardiac toxicity, left ventricular function, twist, echocardiography

About this article
Title

The early variation of left ventricular twisting function in patients with lymphoma received anthracycline therapy assessed by three-dimensional speckle tracking echocardiography

Journal

Cardiology Journal

Issue

Vol 24, No 5 (2017)

Pages

484-494

Published online

2017-03-21

DOI

10.5603/CJ.a2017.0035

Pubmed

28353310

Bibliographic record

Cardiol J 2017;24(5):484-494.

Keywords

anthracycline
cardiac toxicity
left ventricular function
twist
echocardiography

Authors

Feiyan Song
Yu Kang
Chujie Zhang
Yuchen Xu
Jing Shi
Ye Guo
Qunling Zhang
Xianhong Shu
Leilei Cheng

References (52)
  1. DeSantis CE, Lin CC, Mariotto AB, et al. Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin. 2014; 64(4): 252–271.
  2. Haddy N, Mousannif A, Tukenova M, et al. Role of cancer treatment in long-term overall and cardiovascular mortality after childhood cancer. J Clin Oncol. 2010; 28(8): 1308–1315.
  3. Mertens AC, Liu Qi, Neglia JP, et al. Cause-specific late mortality among 5-year survivors of childhood cancer: the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2008; 100(19): 1368–1379.
  4. Notomi Y, Lysyansky P, Setser RM, et al. Measurement of ventricular torsion by two-dimensional ultrasound speckle tracking imaging. J Am Coll Cardiol. 2005; 45(12): 2034–2041.
  5. Rüssel IK, Götte MJW, Bronzwaer JG, et al. Left ventricular torsion: an expanding role in the analysis of myocardial dysfunction. JACC Cardiovasc Imaging. 2009; 2(5): 648–655.
  6. Cutrì E, Serrani M, Bagnoli P, et al. The cardiac torsion as a sensitive index of heart pathology: A model study. J Mech Behav Biomed Mater. 2015; 55: 104–119.
  7. Kowallick JT, Lamata P, Hussain ST, et al. Quantification of left ventricular torsion and diastolic recoil using cardiovascular magnetic resonance myocardial feature tracking. PLoS One. 2014; 9(10): e109164.
  8. Zhong SW, Zhang YQ, Chen LJ, et al. Ventricular twisting and dyssynchrony in children with single left ventricle using three-dimensional speckle tracking imaging after the fontan operation. Echocardiography. 2016; 33(4): 606–617.
  9. Zhou X, Thavendiranathan P, Chen Y, et al. Feasibility of automated three-dimensional rotational mechanics by real-time volume transthoracic echocardiography: Preliminary accuracy and reproducibility data compared with cardiovascular magnetic resonance. J Am Soc Echocardiogr. 2016; 29(1): 62–73.
  10. Lang RM, Bierig M, Devereux RB, et al. Recommendations for chamber quantification. Eur J Echocardiogr. 2006; 28(12): 79–108.
  11. Freund Y, Chenevier-Gobeaux C, Bonnet P, et al. High-sensitivity versus conventional troponin in the emergency department for the diagnosis of acute myocardial infarction. Crit Care. 2011; 15(3): R147.
  12. Cardinale D, Colombo A, Bacchiani G, et al. Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy. Circulation. 2015; 131(22): 1981–1988.
  13. van der Pal HJ, van Dalen EC, van Delden E, et al. High risk of symptomatic cardiac events in childhood cancer survivors. J Clin Oncol. 2012; 30(13): 1429–1437.
  14. van der Pal HJ, van Dalen EC, Hauptmann M, et al. Cardiac function in 5-year survivors of childhood cancer: a long-term follow-up study. Arch Intern Med. 2010; 170(14): 1247–1255.
  15. Gianni L, Herman EH, Lipshultz SE, et al. Anthracycline cardiotoxicity: from bench to bedside. J Clin Oncol. 2008; 26(22): 3777–3784.
  16. Rickard J, Kumbhani DJ, Baranowski B, et al. Usefulness of cardiac resynchronization therapy in patients with adriamycin-induced cardiomyopathy. Am J Cardiol. 2010; 105(4): 522–526.
  17. Chen B, Peng X, Pentassuglia L, et al. Molecular and cellular mechanisms of anthracycline cardiotoxicity. Cardiovasc Toxicol. 2007; 7(2): 114–121.
  18. Mast TP, Teske AJ, Doevendans PA, et al. Current and future role of echocardiography in arrhythmogenic right ventricular dysplasia/cardiomyopathy. Cardiol J. 2015; 22(4): 362–374.
  19. Lipiec P, Wejner-Mik P, Wdowiak-Okrojek K, et al. Fusion of morphological data obtained by coronary computed tomography angiography with quantitative echocardiographic data on regional myocardial function. Cardiol J. 2016; 23(3): 264–269.
  20. Kang Yu, Cheng L, Cui J, et al. A new score system for predicting response to cardiac resynchronization therapy. Cardiol J. 2015; 22(2): 179–187.
  21. Jenkins C, Chan J, Hanekom L, et al. Accuracy and feasibility of online 3-dimensional echocardiography for measurement of left ventricular parameters. J Am Soc Echocardiogr. 2006; 19(9): 1119–1128.
  22. Burri MV, Gupta D, Kerber RE, et al. Review of novel clinical applications of advanced, real-time, 3-dimensional echocardiography. Transl Res. 2012; 159(3): 149–164.
  23. Vamvakidou A, Gurunathan S, Senior R. Novel techniques in stress echocardiography: A focus on the advantages and disadvantages. Expert Rev Cardiovasc Ther. 2016; 14(4): 477–494.
  24. Luis SA, Yamada A, Khandheria BK, et al. Use of three-dimensional speckle-tracking echocardiography for quantitative assessment of global left ventricular function: a comparative study to three-dimensional echocardiography. J Am Soc Echocardiogr. 2014; 27(3): 285–291.
  25. Jasaityte R, Heyde B, D'hooge J. Current state of three-dimensional myocardial strain estimation using echocardiography. J Am Soc Echocardiogr. 2013; 26(1): 15–28.
  26. Seo Y, Ishizu T, Aonuma K. Current status of 3-dimensional speckle tracking echocardiography: A review from our experiences. J Cardiovasc Ultrasound. 2014; 22(2): 49–57.
  27. Cheung Yf, Li Sn, Chan GCF, et al. Left ventricular twisting and untwisting motion in childhood cancer survivors. Echocardiography. 2011; 28(7): 738–745.
  28. Yu Hk, Yu W, Cheuk DKL, et al. New three-dimensional speckle-tracking echocardiography identifies global impairment of left ventricular mechanics with a high sensitivity in childhood cancer survivors. J Am Soc Echocardiogr. 2013; 26(8): 846–852.
  29. Motoki H, Koyama J, Nakazawa H, et al. Torsion analysis in the early detection of anthracycline-mediated cardiomyopathy. Eur Heart J Cardiovasc Imaging. 2012; 13(1): 95–103.
  30. Mornoş C, Petrescu L. Early detection of anthracycline-mediated cardiotoxicity: the value of considering both global longitudinal left ventricular strain and twist. Can J Physiol Pharmacol. 2013; 91(8): 601–607.
  31. Sengupta PP, Tajik AJ, Chandrasekaran K, et al. Twist mechanics of the left ventricle: principles and application. JACC Cardiovasc Imaging. 2008; 1(3): 366–376.
  32. Yamaoka M, Yamaguchi S, Suzuki T, et al. Apoptosis in rat cardiac myocytes induced by Fas ligand: priming for Fas-mediated apoptosis with doxorubicin. J Mol Cell Cardiol. 2000; 32(6): 881–889.
  33. Lim CC, Zuppinger C, Guo X, et al. Anthracyclines induce calpain-dependent titin proteolysis and necrosis in cardiomyocytes. J Biol Chem. 2004; 279(9): 8290–8299.
  34. Bell SP, Nyland L, Tischler MD, et al. Alterations in the determinants of diastolic suction during pacing tachycardia. Circ Res. 2000; 87(3): 235–240.
  35. Prinz C, Faber L, Horstkotte D, et al. Evaluation of left ventricular torsion in children with hypertrophic cardiomyopathy. Cardiol Young. 2014; 24(2): 245–252.
  36. Ahmed MI, Desai RV, Gaddam KK, et al. Relation of torsion and myocardial strains to LV ejection fraction in hypertension. JACC Cardiovasc Imaging. 2012; 5(3): 273–281.
  37. Pagourelias ED, Sotiriou P, Papadopoulos CE, et al. Left ventricular myocardial mechanics in cirrhosis: A speckle tracking echocardiographic study. Echocardiography. 2016; 33(2): 223–232.
  38. Di Maria MV, Caracciolo G, Prashker S, et al. Left ventricular rotational mechanics before and after exercise in children. J Am Soc Echocardiogr. 2014; 27(12): 1336–1343.
  39. Aksakal E, Kurt M, Oztürk ME, et al. The effect of incremental endurance exercise training on left ventricular mechanics: a prospective observational deformation imaging study. Anadolu Kardiyol Derg. 2013; 13(5): 432–438.
  40. Sengupta PP, Narula J. Reclassifying heart failure: predominantly subendocardial, subepicardial, and transmural. Heart Fail Clin. 2008; 4(3): 379–382.
  41. Armstrong GT, Joshi VM, Ness KK, et al. Comprehensive echocardiographic detection of treatment-related cardiac dysfunction in adult survivors of childhood cancer: Results from the St. Jude Lifetime Cohort Study. J Am Coll Cardiol. 2015; 65(23): 2511–2522.
  42. Thavendiranathan P, Poulin F, Lim KD, et al. Use of myocardial strain imaging by echocardiography for the early detection of cardiotoxicity in patients during and after cancer chemotherapy: a systematic review. J Am Coll Cardiol. 2014; 63(25 Pt A): 2751–2768.
  43. Zamorano JL, Lancellotti P, Rodriguez Muñoz D, et al. Authors/Task Force Members, ESC Committee for Practice Guidelines (CPG):. 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines:  The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC). Eur Heart J. 2016; 37(36): 2768–2801.
  44. Lang RM, Badano LP, Mor-Avi V, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2015; 28(1): 1–39.e14.
  45. Tan TC, Bouras S, Sawaya H, et al. Time trends of left ventricular ejection fraction and myocardial deformation indices in a cohort of women with breast cancer treated with anthracyclines, taxanes, and trastuzumab. J Am Soc Echocardiogr. 2015; 28(5): 509–514.
  46. Moja L, Tagliabue L, Balduzzi S, et al. Trastuzumab containing regimens for early breast cancer. Cochrane Database Syst Rev. 2012(4): CD006243.
  47. Guarneri V, Lenihan DJ, Valero V, et al. Long-term cardiac tolerability of trastuzumab in metastatic breast cancer: the M.D. Anderson Cancer Center experience. J Clin Oncol. 2006; 24(25): 4107–4115.
  48. Khan AA, Ashraf A, Singh R, et al. Incidence, time of occurrence and response to heart failure therapy in patients with anthracycline cardiotoxicity. Intern Med J. 2017; 47(1): 104–109.
  49. Kang Yu, Xu X, Cheng L, et al. Two-dimensional speckle tracking echocardiography combined with high-sensitive cardiac troponin T in early detection and prediction of cardiotoxicity during epirubicine-based chemotherapy. Eur J Heart Fail. 2014; 16(3): 300–308.
  50. Sanchis J, Bardají A, Bosch X, et al. N-terminal pro-brain natriuretic peptide and high-sensitivity troponin in the evaluation of acute chest pain of uncertain etiology. A PITAGORAS substudy. Rev Esp Cardiol (Engl Ed). 2013; 66(7): 532–538.
  51. Blaes AH, Rehman A, Vock DM, et al. Utility of high-sensitivity cardiac troponin T in patients receiving anthracycline chemotherapy. Vasc Health Risk Manag. 2015; 11: 591–594.
  52. Zidan A, Sherief LM, El-sheikh A, et al. NT-proBNP as early marker of subclinical late cardiotoxicity after doxorubicin therapy and mediastinal irradiation in childhood cancer survivors. Dis Markers. 2015; 2015: 513219.

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