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open access

Vol 29, No 5 (2022)
Review Article
Submitted: 2020-10-13
Accepted: 2020-12-22
Published online: 2021-01-14
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Does kidney function matter in pulmonary thromboembolism management?

Magdalena Pływaczewska1, Piotr Pruszczyk1, Maciej Kostrubiec1
DOI: 10.5603/CJ.a2021.0005
·
Pubmed: 33470418
·
Cardiol J 2022;29(5):858-865.
Affiliations
  1. Department of Inter nal Medicine and Car diology, Medical University of Warsaw, Poland

open access

Vol 29, No 5 (2022)
Review articles — Clinical cardiology
Submitted: 2020-10-13
Accepted: 2020-12-22
Published online: 2021-01-14

Abstract

Cardiovascular circulation and kidney function are closely interrelated. The impairment of renal function is a well-known hazard of increased mortality and morbidity of patients with heart failure or coronary artery disease. Acute pulmonary embolism (APE) impacts pulmonary and systemic circulation, and can severely impair functions of other organs, including kidneys, as a result of hypoxemia and increased venous pressure. Previous studies indicate that renal dysfunction predicts short- and long-term outcomes and can improve the risk assessment in APE. However, renal function should also be cautiously considered during the diagnostic workup because the contrast-induced nephropathy after computed tomography pulmonary angiography is noticed more frequently in APE. Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare but imminent complication of APE. This condition promotes renal impairment by increasing venous pressure and decreasing glomerular filtration. The renal function improvement and serum creatinine concentration reduction were noted in CTEPH subgroup with glomerular filtration rate ≤ 60 mL/min/1.73 m2 after successful treatment. In this review, we present the essential research results on the kidney function in thromboembolism disease.

Abstract

Cardiovascular circulation and kidney function are closely interrelated. The impairment of renal function is a well-known hazard of increased mortality and morbidity of patients with heart failure or coronary artery disease. Acute pulmonary embolism (APE) impacts pulmonary and systemic circulation, and can severely impair functions of other organs, including kidneys, as a result of hypoxemia and increased venous pressure. Previous studies indicate that renal dysfunction predicts short- and long-term outcomes and can improve the risk assessment in APE. However, renal function should also be cautiously considered during the diagnostic workup because the contrast-induced nephropathy after computed tomography pulmonary angiography is noticed more frequently in APE. Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare but imminent complication of APE. This condition promotes renal impairment by increasing venous pressure and decreasing glomerular filtration. The renal function improvement and serum creatinine concentration reduction were noted in CTEPH subgroup with glomerular filtration rate ≤ 60 mL/min/1.73 m2 after successful treatment. In this review, we present the essential research results on the kidney function in thromboembolism disease.

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Keywords

renal dysfunction, contrast-induced nephropathy, pulmonary embolism, chronic thromboembolic pulmonary hypertension, prognosis, mortality

About this article
Title

Does kidney function matter in pulmonary thromboembolism management?

Journal

Cardiology Journal

Issue

Vol 29, No 5 (2022)

Article type

Review Article

Pages

858-865

Published online

2021-01-14

Page views

4789

Article views/downloads

1522

DOI

10.5603/CJ.a2021.0005

Pubmed

33470418

Bibliographic record

Cardiol J 2022;29(5):858-865.

Keywords

renal dysfunction
contrast-induced nephropathy
pulmonary embolism
chronic thromboembolic pulmonary hypertension
prognosis
mortality

Authors

Magdalena Pływaczewska
Piotr Pruszczyk
Maciej Kostrubiec

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