open access

Vol 20, No 3 (2013)
Original articles
Published online: 2013-06-01
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Aortic valve sclerosis is a sign of increased arterial stiffness in clinically asymptomatic subjects

Levent Korkmaz, Mustafa Tarık Ağaç, Huseyin Bektas, Mustafa Oguz Varol, Hakan Erkan, Zeydin Acar, Devrim Kurt, Şükrü Çelik
DOI: 10.5603/CJ.2013.0078
·
Cardiol J 2013;20(3):318-322.

open access

Vol 20, No 3 (2013)
Original articles
Published online: 2013-06-01

Abstract

Background: Classic risk scores may under estimate the risk of cardiovascular (CV) events in specific risk groups requiring appropriate medical and interventional treatment. Arterialstiffness has been known as a sign of CV risk and has a predictive value for CV events beyond classic CV risk factors. The purpose of this study was to investigate the relation between thecardio-ankle vascular index (CAVI) that has been recently reported as a new surrogate marker of arterial stiffness and aortic valve sclerosis (AVS).

Methods: Eighty patients with AVS and 80 control subjects were enrolled to the study. Arterial stiffness was evaluated by VaSera-1000 CAVI instrument and AVS was defined by echocardiography as thickening and calcification of the normal trileaflet aortic valve without obstruction to the left ventricular outflow.

Results: CAVI was significantly higher in patients with AVS compared to the control subjects (10.5 ± 2.7 vs. 8.6 ± 1.4, p < 0.001). Higher frequency of AVS was detected in patients with abnormal than borderline and normal CAVI values (69% vs. 27% and 20%, respectively, p < 0.001). In univariate analysis, there was a significant association between AVS and CAVI (95% confidence interval [CI] 1.44–2.48, p < 0.001]. Multivariate analysis demonstrated CAVI (95% CI 1.39–2.44, p < 0.001) as an independent determinant of AVS.

Conclusions: Detection of increased arterial stiffness could prevent patients from being mistakenly classified as at low or moderate risk, when they actually are at high risk. Assessment of aortic valve during echocardiography examination may offer the opportunity to identify these subjects.

Abstract

Background: Classic risk scores may under estimate the risk of cardiovascular (CV) events in specific risk groups requiring appropriate medical and interventional treatment. Arterialstiffness has been known as a sign of CV risk and has a predictive value for CV events beyond classic CV risk factors. The purpose of this study was to investigate the relation between thecardio-ankle vascular index (CAVI) that has been recently reported as a new surrogate marker of arterial stiffness and aortic valve sclerosis (AVS).

Methods: Eighty patients with AVS and 80 control subjects were enrolled to the study. Arterial stiffness was evaluated by VaSera-1000 CAVI instrument and AVS was defined by echocardiography as thickening and calcification of the normal trileaflet aortic valve without obstruction to the left ventricular outflow.

Results: CAVI was significantly higher in patients with AVS compared to the control subjects (10.5 ± 2.7 vs. 8.6 ± 1.4, p < 0.001). Higher frequency of AVS was detected in patients with abnormal than borderline and normal CAVI values (69% vs. 27% and 20%, respectively, p < 0.001). In univariate analysis, there was a significant association between AVS and CAVI (95% confidence interval [CI] 1.44–2.48, p < 0.001]. Multivariate analysis demonstrated CAVI (95% CI 1.39–2.44, p < 0.001) as an independent determinant of AVS.

Conclusions: Detection of increased arterial stiffness could prevent patients from being mistakenly classified as at low or moderate risk, when they actually are at high risk. Assessment of aortic valve during echocardiography examination may offer the opportunity to identify these subjects.

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Keywords

aortic valve sclerosis, arterial stiffness, cardio-ankle vascular index

About this article
Title

Aortic valve sclerosis is a sign of increased arterial stiffness in clinically asymptomatic subjects

Journal

Cardiology Journal

Issue

Vol 20, No 3 (2013)

Pages

318-322

Published online

2013-06-01

DOI

10.5603/CJ.2013.0078

Bibliographic record

Cardiol J 2013;20(3):318-322.

Keywords

aortic valve sclerosis
arterial stiffness
cardio-ankle vascular index

Authors

Levent Korkmaz
Mustafa Tarık Ağaç
Huseyin Bektas
Mustafa Oguz Varol
Hakan Erkan
Zeydin Acar
Devrim Kurt
Şükrü Çelik

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