open access

Vol 19, No 1 (2012)
Original articles
Published online: 2012-02-02
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Severe chronic heart failure in patients considered for heart transplantation in Poland*

Jerzy Korewicki, Przemysław Leszek, Tomasz Zieliński, Tomasz Rywik, Walerian Piotrowski, Paweł Kurjata, Katarzyna Kozar-Kamińska, Katarzyna Kodziszewska
Cardiol J 2012;19(1):36-44.

open access

Vol 19, No 1 (2012)
Original articles
Published online: 2012-02-02

Abstract

Background: Based on the results of clinical trials, the prognosis for patients with severe heart failure (HF) has improved over the last 20 years. However, clinical trials do not reflect ‘real life’ due to patient selection. Thus, the aim of the POLKARD-HF registry was the analysis of survival of patients with refractory HF referred for orthotopic heart transplantation (OHT).
Methods: Between 1 November 2003 and 31 October 2007, 983 patients with severe HF, referred for OHT in Poland, were included into the registry. All patients underwent routine clinical and hemodynamic evaluation, with NT-proBNP and hsCRP assessment. Death or an emergency OHT were assumed as the endpoints. The average observation period was 601 days. Kaplan-Meier curves with log-rank and univariate together with multifactor Cox regression model the stepwise variable selection method were used to determine the predictive value of analyzed variables.
Results:
Among the 983 patients, the probability of surviving for one year was approximately 80%, for two years 70%, and for three years 67%. Etiology of the HF did not significantly influence the prognosis. The patients in NYHA class IV had a three-fold higher risk of death or emergency OHT. The univariate/multifactor Cox regression analysis revealed that NYHA IV class (HR 2.578, p < 0.0001), HFSS score (HR 2.572, p < 0.0001) and NT-proBNP plasma level (HR 1.600, p = 0.0200), proved to influence survival without death or emergency OHT.
Conclusions: Despite optimal treatment, the prognosis for patients with refractory HF is still not good. NYHA class IV, NT-proBNP and HFSS score can help define the highest risk group. The results are consistent with the prognosis of patients enrolled into the randomized trials. (Cardiol J 2012; 19, 1: 36–44)

Abstract

Background: Based on the results of clinical trials, the prognosis for patients with severe heart failure (HF) has improved over the last 20 years. However, clinical trials do not reflect ‘real life’ due to patient selection. Thus, the aim of the POLKARD-HF registry was the analysis of survival of patients with refractory HF referred for orthotopic heart transplantation (OHT).
Methods: Between 1 November 2003 and 31 October 2007, 983 patients with severe HF, referred for OHT in Poland, were included into the registry. All patients underwent routine clinical and hemodynamic evaluation, with NT-proBNP and hsCRP assessment. Death or an emergency OHT were assumed as the endpoints. The average observation period was 601 days. Kaplan-Meier curves with log-rank and univariate together with multifactor Cox regression model the stepwise variable selection method were used to determine the predictive value of analyzed variables.
Results:
Among the 983 patients, the probability of surviving for one year was approximately 80%, for two years 70%, and for three years 67%. Etiology of the HF did not significantly influence the prognosis. The patients in NYHA class IV had a three-fold higher risk of death or emergency OHT. The univariate/multifactor Cox regression analysis revealed that NYHA IV class (HR 2.578, p < 0.0001), HFSS score (HR 2.572, p < 0.0001) and NT-proBNP plasma level (HR 1.600, p = 0.0200), proved to influence survival without death or emergency OHT.
Conclusions: Despite optimal treatment, the prognosis for patients with refractory HF is still not good. NYHA class IV, NT-proBNP and HFSS score can help define the highest risk group. The results are consistent with the prognosis of patients enrolled into the randomized trials. (Cardiol J 2012; 19, 1: 36–44)
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Keywords

acute chronic heart failure; prognosis; risk factors; POLKARD-HF

About this article
Title

Severe chronic heart failure in patients considered for heart transplantation in Poland*

Journal

Cardiology Journal

Issue

Vol 19, No 1 (2012)

Pages

36-44

Published online

2012-02-02

Bibliographic record

Cardiol J 2012;19(1):36-44.

Keywords

acute chronic heart failure
prognosis
risk factors
POLKARD-HF

Authors

Jerzy Korewicki
Przemysław Leszek
Tomasz Zieliński
Tomasz Rywik
Walerian Piotrowski
Paweł Kurjata
Katarzyna Kozar-Kamińska
Katarzyna Kodziszewska

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