Vol 19, No 1 (2012)
Review Article
Published online: 2012-02-02
ARISTOTLE RE-LYs on the ROCKET. What’s new in stroke prevention in patients with atrial fibrillation?
Cardiol J 2012;19(1):4-10.
Abstract
Warfarin has long been considered the gold standard for stroke prevention in patients with atrial fibrillation (AF). Recently, three major trials comparing the efficacy and safety of new
drugs: a thrombin inhibitor dabigatran and two inhibitors of factor Xa — rivaroxaban and
apixaban, with that of warfarin, have been published. The aim of this paper is to present the
main results of the RE-LY, ROCKET AF and ARISTOTLE trials, compare study populations
and outcomes, and discuss clinical implications of their results for the long-term anticoagulation
in patients with nonvalvular AF. (Cardiol J 2012; 19, 1: 4–10)
Keywords: atrial fibrillationstroke preventionapixabandabigatranrivaroxaban
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