open access

Vol 19, No 4 (2012)
Original articles
Published online: 2012-07-09
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Evaluation of left ventricular systolic asynchrony in patients with subclinical hypothyroidism

Serkan Ozturk, Aytekin Alcelik, Mehmet Ozyasar, Oguz Dikbas, Selim Ayhan, Fatih Ozlu, Alim Erdem, Mehmet Tosun, Davut Baltaci, Mehmet Yazici
Cardiol J 2012;19(4):374-380.

open access

Vol 19, No 4 (2012)
Original articles
Published online: 2012-07-09

Abstract

Background: The heart was very sensitive to fluctuating thyroid hormone levels. To assess intra-left ventricular (LV) systolic asynchrony in patients with subclinical thyroid dysfunction.

Methods: Fifty patients with subclinical hypothyroidism and 40 controls were included. A diagnosis of subclinical hypothyroidism was reached with increased TSH and normal free T4. All subjects were evaluated by echocardiography. Evaluation of intra-LV systolic asynchrony was performed by tissue synchronization imaging (TSI), and four TSI parameters of systolic asynchrony were calculated. LV asynchrony was defined by these parameters.

Results: All of the groups were similar in terms of demographic findings and conventional and Doppler echocardiograpic parameters except peak systolic velocity and early diastolic velocity. LV systolic asynchrony parameters of TSI including; standard deviation of Ts of the 12 LV segments (Ts-SD-12), maximal difference in Ts between any 2 of the 12 LV segments (Ts-12), standard deviation of TS of the 6 basal LV segments (Ts-SD-6), maximal difference in Ts between any of the 6 basal LV segments (Ts-6) were significantly lengthened in patients with subclinical hypothyroidism than controls (p < 0.001, p < 0.001, p < 0.001 and p < 0.001, respectively). The prevalence of LV asynchrony was significantly higher in patients with subclinical hypothyroidism than control.

Conclusions: Patients with subclinical hypothyroidism present evidence of LV asynchrony by TSI. LV systolic asynchrony could be a warning sign of the early stage in cardiac systolic dysfunction in subclinical hypothyroid patients.

Abstract

Background: The heart was very sensitive to fluctuating thyroid hormone levels. To assess intra-left ventricular (LV) systolic asynchrony in patients with subclinical thyroid dysfunction.

Methods: Fifty patients with subclinical hypothyroidism and 40 controls were included. A diagnosis of subclinical hypothyroidism was reached with increased TSH and normal free T4. All subjects were evaluated by echocardiography. Evaluation of intra-LV systolic asynchrony was performed by tissue synchronization imaging (TSI), and four TSI parameters of systolic asynchrony were calculated. LV asynchrony was defined by these parameters.

Results: All of the groups were similar in terms of demographic findings and conventional and Doppler echocardiograpic parameters except peak systolic velocity and early diastolic velocity. LV systolic asynchrony parameters of TSI including; standard deviation of Ts of the 12 LV segments (Ts-SD-12), maximal difference in Ts between any 2 of the 12 LV segments (Ts-12), standard deviation of TS of the 6 basal LV segments (Ts-SD-6), maximal difference in Ts between any of the 6 basal LV segments (Ts-6) were significantly lengthened in patients with subclinical hypothyroidism than controls (p < 0.001, p < 0.001, p < 0.001 and p < 0.001, respectively). The prevalence of LV asynchrony was significantly higher in patients with subclinical hypothyroidism than control.

Conclusions: Patients with subclinical hypothyroidism present evidence of LV asynchrony by TSI. LV systolic asynchrony could be a warning sign of the early stage in cardiac systolic dysfunction in subclinical hypothyroid patients.

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Keywords

left ventricular asynchrony; thyroid stimulating hormone; tissue synchronization imaging

About this article
Title

Evaluation of left ventricular systolic asynchrony in patients with subclinical hypothyroidism

Journal

Cardiology Journal

Issue

Vol 19, No 4 (2012)

Pages

374-380

Published online

2012-07-09

Bibliographic record

Cardiol J 2012;19(4):374-380.

Keywords

left ventricular asynchrony
thyroid stimulating hormone
tissue synchronization imaging

Authors

Serkan Ozturk
Aytekin Alcelik
Mehmet Ozyasar
Oguz Dikbas
Selim Ayhan
Fatih Ozlu
Alim Erdem
Mehmet Tosun
Davut Baltaci
Mehmet Yazici

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