open access

Vol 14, No 1 (2007)
Original articles
Published online: 2006-12-01
Get Citation

Obesity and adiponectin in acute myocardial infarction

Katarzyna Piestrzeniewicz, Katarzyna Łuczak, Jan Komorowski, Marek Maciejewski, Monika Piechowiak, Joanna Jankiewicz-Wika i Jan Henryk Goch
Cardiol J 2007;14(1):29-36.

open access

Vol 14, No 1 (2007)
Original articles
Published online: 2006-12-01

Abstract

Background: Low plasma concentration of adiponectin, a hormone-like peptide secreted by adipose tissue, is detected in obesity and in coronary artery disease. The aim of the study was to assess the impact of obesity on adiponectin and the relation of adiponectin to the anthropometric parameters and cardiovascular risk factors in men with acute myocardial infarction.
Methods: Two groups of patients with first acute myocardial infarction were analyzed: 40 obese and 40 non-obese men. Waist and hip circumferences and waist-to-hip ratio, C-reactive protein (CRP), uric acid, fasting glucose, lipid profile and adiponectin were measured.
Results: Mean level of adiponectin was significantly lower in obese than non-obese patients (6.80 μg/ml ± 4.31 vs. 11.18 μg/ml ± 7.19; p < 0.01). Adiponectin levels correlated negatively with all anthropometric measurements, the most significantly with waist circumference, with systolic blood pressure, fasting glucose, triglyceride levels, CRP, uric acid and positively with age and HDL-cholesterol. Adiponectin level was significantly associated with HDL-cholesterol, waist circumference and with trigliceryde levels and these independent variables explained 39% of the plasma adiponectin variability.
Conclusions: In patients with acute myocardial infarction obesity is related to decreased adiponectin. Low adiponectin level is associated with atherogenic lipid profile and higher levels of inflammatory markers. (Cardiol J 2007; 14: 29–36)

Abstract

Background: Low plasma concentration of adiponectin, a hormone-like peptide secreted by adipose tissue, is detected in obesity and in coronary artery disease. The aim of the study was to assess the impact of obesity on adiponectin and the relation of adiponectin to the anthropometric parameters and cardiovascular risk factors in men with acute myocardial infarction.
Methods: Two groups of patients with first acute myocardial infarction were analyzed: 40 obese and 40 non-obese men. Waist and hip circumferences and waist-to-hip ratio, C-reactive protein (CRP), uric acid, fasting glucose, lipid profile and adiponectin were measured.
Results: Mean level of adiponectin was significantly lower in obese than non-obese patients (6.80 μg/ml ± 4.31 vs. 11.18 μg/ml ± 7.19; p < 0.01). Adiponectin levels correlated negatively with all anthropometric measurements, the most significantly with waist circumference, with systolic blood pressure, fasting glucose, triglyceride levels, CRP, uric acid and positively with age and HDL-cholesterol. Adiponectin level was significantly associated with HDL-cholesterol, waist circumference and with trigliceryde levels and these independent variables explained 39% of the plasma adiponectin variability.
Conclusions: In patients with acute myocardial infarction obesity is related to decreased adiponectin. Low adiponectin level is associated with atherogenic lipid profile and higher levels of inflammatory markers. (Cardiol J 2007; 14: 29–36)
Get Citation

Keywords

obesity; adiponectin; myocardial infarction

About this article
Title

Obesity and adiponectin in acute myocardial infarction

Journal

Cardiology Journal

Issue

Vol 14, No 1 (2007)

Pages

29-36

Published online

2006-12-01

Bibliographic record

Cardiol J 2007;14(1):29-36.

Keywords

obesity
adiponectin
myocardial infarction

Authors

Katarzyna Piestrzeniewicz
Katarzyna Łuczak
Jan Komorowski
Marek Maciejewski
Monika Piechowiak
Joanna Jankiewicz-Wika i Jan Henryk Goch

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: viamedica@viamedica.pl