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Obesity and adiponectin in acute myocardial infarction
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Abstract
Methods: Two groups of patients with first acute myocardial infarction were analyzed: 40 obese and 40 non-obese men. Waist and hip circumferences and waist-to-hip ratio, C-reactive protein (CRP), uric acid, fasting glucose, lipid profile and adiponectin were measured.
Results: Mean level of adiponectin was significantly lower in obese than non-obese patients (6.80 μg/ml ± 4.31 vs. 11.18 μg/ml ± 7.19; p < 0.01). Adiponectin levels correlated negatively with all anthropometric measurements, the most significantly with waist circumference, with systolic blood pressure, fasting glucose, triglyceride levels, CRP, uric acid and positively with age and HDL-cholesterol. Adiponectin level was significantly associated with HDL-cholesterol, waist circumference and with trigliceryde levels and these independent variables explained 39% of the plasma adiponectin variability.
Conclusions: In patients with acute myocardial infarction obesity is related to decreased adiponectin. Low adiponectin level is associated with atherogenic lipid profile and higher levels of inflammatory markers. (Cardiol J 2007; 14: 29–36)
Abstract
Methods: Two groups of patients with first acute myocardial infarction were analyzed: 40 obese and 40 non-obese men. Waist and hip circumferences and waist-to-hip ratio, C-reactive protein (CRP), uric acid, fasting glucose, lipid profile and adiponectin were measured.
Results: Mean level of adiponectin was significantly lower in obese than non-obese patients (6.80 μg/ml ± 4.31 vs. 11.18 μg/ml ± 7.19; p < 0.01). Adiponectin levels correlated negatively with all anthropometric measurements, the most significantly with waist circumference, with systolic blood pressure, fasting glucose, triglyceride levels, CRP, uric acid and positively with age and HDL-cholesterol. Adiponectin level was significantly associated with HDL-cholesterol, waist circumference and with trigliceryde levels and these independent variables explained 39% of the plasma adiponectin variability.
Conclusions: In patients with acute myocardial infarction obesity is related to decreased adiponectin. Low adiponectin level is associated with atherogenic lipid profile and higher levels of inflammatory markers. (Cardiol J 2007; 14: 29–36)
Keywords
obesity; adiponectin; myocardial infarction
About this articleTitle
Obesity and adiponectin in acute myocardial infarction
Journal
Issue
Pages
29-36
Published online
2006-12-01
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931
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Bibliographic record
Cardiol J 2007;14(1):29-36.
Keywords
obesity
adiponectin
myocardial infarction
Authors
Katarzyna Piestrzeniewicz
Katarzyna Łuczak
Jan Komorowski
Marek Maciejewski
Monika Piechowiak
Joanna Jankiewicz-Wika i Jan Henryk Goch
