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Assessment of right ventriclar function by tissue Doppler in relation to plasma NT-proBNP concentration in patients with dilated cardiomyopathy
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Abstract
Background: Impairment of right ventricular function is a common finding in patients with dilated cardiomyopathy (DCM). The aim of the study was to assess the function of the right ventricle by tissue Doppler imaging (TDI) in relation to NT-proBNP concentration in patients with DCM.
Methods: 29 patients with DCM were studied. Group I (n = 21) constituted of subjects with a NT-proBNP concentration > 500 pg/ml and group II (n = 8) constituted of patients with NT-proBNP < 500 pg/ml. In all patients the TDI parameters for the free-wall of the right ventricle were analysed: velocity of myocardium (VEL), strain (ε) and strain rate (SR).
Results: There were no significant differences between the two groups with respect to clinical characteristics, parameters of global and regional left ventricular systolic function or between indicators of global right ventricular function. In group I the maximal values of e in the apical and medial segments of the right ventricular free wall were significantly lower than in group II (-17 ± 10 vs. -29 ± 7%; p = 0.0168 and -13 ± 6 vs. -25 ± 5%; p = 0.0023 respectively). Moreover, in group I the maximal SR in the apical and medial segments of the right ventricular free wall were significantly lower than in group II (1.56 ± 0.6 ε-1 vs. -1.071 ± 0.5 ε-1; p = 0.0358 and -0.99 ± 0.38 ε-1 vs. -1.55 ± 0.37 ε-1; p = 0.0044 respectively).
Conclusions: Impairment of right ventricular function is most visible in the apical and medial segments. The maximal values of e and SR for the right ventricle free wall are lower in patients with DCM and NT-proBNP > 500 pg/ml. (Cardiol J 2007; 14: 167-173)
Abstract
Background: Impairment of right ventricular function is a common finding in patients with dilated cardiomyopathy (DCM). The aim of the study was to assess the function of the right ventricle by tissue Doppler imaging (TDI) in relation to NT-proBNP concentration in patients with DCM.
Methods: 29 patients with DCM were studied. Group I (n = 21) constituted of subjects with a NT-proBNP concentration > 500 pg/ml and group II (n = 8) constituted of patients with NT-proBNP < 500 pg/ml. In all patients the TDI parameters for the free-wall of the right ventricle were analysed: velocity of myocardium (VEL), strain (ε) and strain rate (SR).
Results: There were no significant differences between the two groups with respect to clinical characteristics, parameters of global and regional left ventricular systolic function or between indicators of global right ventricular function. In group I the maximal values of e in the apical and medial segments of the right ventricular free wall were significantly lower than in group II (-17 ± 10 vs. -29 ± 7%; p = 0.0168 and -13 ± 6 vs. -25 ± 5%; p = 0.0023 respectively). Moreover, in group I the maximal SR in the apical and medial segments of the right ventricular free wall were significantly lower than in group II (1.56 ± 0.6 ε-1 vs. -1.071 ± 0.5 ε-1; p = 0.0358 and -0.99 ± 0.38 ε-1 vs. -1.55 ± 0.37 ε-1; p = 0.0044 respectively).
Conclusions: Impairment of right ventricular function is most visible in the apical and medial segments. The maximal values of e and SR for the right ventricle free wall are lower in patients with DCM and NT-proBNP > 500 pg/ml. (Cardiol J 2007; 14: 167-173)
Keywords
dilated cardiomyopathy; ventricular function; Doppler echocardiography; NT-proBNP
About this articleTitle
Assessment of right ventriclar function by tissue Doppler in relation to plasma NT-proBNP concentration in patients with dilated cardiomyopathy
Journal
Issue
Pages
167-173
Published online
2007-03-08
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726
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Bibliographic record
Cardiol J 2007;14(2):167-173.
Keywords
dilated cardiomyopathy
ventricular function
Doppler echocardiography
NT-proBNP
Authors
Witold Streb
Jolanta Nowak
Anna Śliwińska
Beata Spinczyk
Mariola Szulik
Agata Duszańska
Ewa Uszok-Stenzel
Mariusz Kalinowski
Zbigniew Kalarus
Lech Poloński
Tomasz Kukulski
