open access

Vol 14, No 3 (2007)
Original articles
Published online: 2007-03-30
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The relationship between leptin and obesity and cardiovascular risk factors in men with acute myocardial infarction

Katarzyna Piestrzeniewicz, Katarzyna Łuczak, Jan Komorowski, Marek Maciejewski, Jan Henryk Goch
Cardiol J 2007;14(3):252-259.

open access

Vol 14, No 3 (2007)
Original articles
Published online: 2007-03-30

Abstract


Background: Leptin, a hormone-like peptide secreted by adipose tissue, is a strong correlate of obesity. Conflicting data exist concerning leptin as an independent risk factor of coronary artery disease. The aim of the study was to assess the relationship between leptin and obesity and cardiovascular risk factors in men with acute myocardial infarction.
Methods: Two groups of patients who had experienced their first acute myocardial infarction were analysed: 40 obese and 40 non-obese men. Waist and hip circumferences, waist-to-hip ratio, C-reactive protein (CRP), uric acid, fasting glucose, lipid profile and leptin were measured.
Results: Mean leptin was significantly higher in obese than in non-obese patients (46.7 ng/ml ± 18.7 vs. 15.6 ng/ml ± 11.9; p < 0.01). Leptin levels correlated positively with all anthropometric measurements, fasting glucose, triglyceride levels, CRP and uric acid and negatively with HDL-cholesterol.
Conclusions: In patients with acute myocardial infarction, obesity is related to increased leptin. The subcutaneous fat compartment seems to be an important determinant of plasma leptin concentration. Leptinemia is associated with several biochemical disorders, suggesting that leptin may be a pathogenetic factor in cardiovascular disease. (Cardiol J 2007; 14: 252-259)

Abstract


Background: Leptin, a hormone-like peptide secreted by adipose tissue, is a strong correlate of obesity. Conflicting data exist concerning leptin as an independent risk factor of coronary artery disease. The aim of the study was to assess the relationship between leptin and obesity and cardiovascular risk factors in men with acute myocardial infarction.
Methods: Two groups of patients who had experienced their first acute myocardial infarction were analysed: 40 obese and 40 non-obese men. Waist and hip circumferences, waist-to-hip ratio, C-reactive protein (CRP), uric acid, fasting glucose, lipid profile and leptin were measured.
Results: Mean leptin was significantly higher in obese than in non-obese patients (46.7 ng/ml ± 18.7 vs. 15.6 ng/ml ± 11.9; p < 0.01). Leptin levels correlated positively with all anthropometric measurements, fasting glucose, triglyceride levels, CRP and uric acid and negatively with HDL-cholesterol.
Conclusions: In patients with acute myocardial infarction, obesity is related to increased leptin. The subcutaneous fat compartment seems to be an important determinant of plasma leptin concentration. Leptinemia is associated with several biochemical disorders, suggesting that leptin may be a pathogenetic factor in cardiovascular disease. (Cardiol J 2007; 14: 252-259)
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Keywords

obesity; leptin; myocardial infarction

About this article
Title

The relationship between leptin and obesity and cardiovascular risk factors in men with acute myocardial infarction

Journal

Cardiology Journal

Issue

Vol 14, No 3 (2007)

Pages

252-259

Published online

2007-03-30

Bibliographic record

Cardiol J 2007;14(3):252-259.

Keywords

obesity
leptin
myocardial infarction

Authors

Katarzyna Piestrzeniewicz
Katarzyna Łuczak
Jan Komorowski
Marek Maciejewski
Jan Henryk Goch

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