Vol 14, No 3 (2007)
Original articles
Published online: 2007-03-30

open access

Page views 780
Article views/downloads 1419
Get Citation

Connect on Social Media

Connect on Social Media

The relationship between leptin and obesity and cardiovascular risk factors in men with acute myocardial infarction

Katarzyna Piestrzeniewicz, Katarzyna Łuczak, Jan Komorowski, Marek Maciejewski, Jan Henryk Goch
Cardiol J 2007;14(3):252-259.

Abstract


Background: Leptin, a hormone-like peptide secreted by adipose tissue, is a strong correlate of obesity. Conflicting data exist concerning leptin as an independent risk factor of coronary artery disease. The aim of the study was to assess the relationship between leptin and obesity and cardiovascular risk factors in men with acute myocardial infarction.
Methods: Two groups of patients who had experienced their first acute myocardial infarction were analysed: 40 obese and 40 non-obese men. Waist and hip circumferences, waist-to-hip ratio, C-reactive protein (CRP), uric acid, fasting glucose, lipid profile and leptin were measured.
Results: Mean leptin was significantly higher in obese than in non-obese patients (46.7 ng/ml ± 18.7 vs. 15.6 ng/ml ± 11.9; p < 0.01). Leptin levels correlated positively with all anthropometric measurements, fasting glucose, triglyceride levels, CRP and uric acid and negatively with HDL-cholesterol.
Conclusions: In patients with acute myocardial infarction, obesity is related to increased leptin. The subcutaneous fat compartment seems to be an important determinant of plasma leptin concentration. Leptinemia is associated with several biochemical disorders, suggesting that leptin may be a pathogenetic factor in cardiovascular disease. (Cardiol J 2007; 14: 252-259)

Article available in PDF format

View PDF Download PDF file