open access

Vol 14, No 4 (2007)
Case Reports
Published online: 2007-06-11
Submitted: 2013-01-14
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Case reports

D. Bortolo Martini, Claudio Sperotto, Li Zhang
Cardiol J 2007;14(4):407-410.

open access

Vol 14, No 4 (2007)
Case Reports
Published online: 2007-06-11
Submitted: 2013-01-14

Abstract

Whether to a greater or lesser extent, genetics often plays an important role in the development of cardiovascular diseases. Here we report a newly identified family with familial coronary artery disease (CAD) and left ventricular non-compaction (LVNC).
A 52-year-old male with acute coronary syndrome, in whom LVNC had been found "incidentally", was admitted for revascularisation. From a two-dimensional echocardiogram the epicardial layer appeared to be thin and compacted, but the apical endocardial layer of the left ventricle was extremely thickened with prominent trabeculations in the endocardial layer and deep intertrabecular recesses in a channel-like structure. Family history revealed that his 47-year-old brother also had LVNC but to a lesser degree. Their mother had two false tendons in the left ventricular apex and both parents had severe CAD.
Left ventricular non-compaction is "incidentally" identified in a kindred with familial CAD. The disease expressivity varies among affected individuals. Whether it is coincidental or there is a genetic link is a question that awaits further investigation. (Cardiol J 2007; 14: 407-410)

Abstract

Whether to a greater or lesser extent, genetics often plays an important role in the development of cardiovascular diseases. Here we report a newly identified family with familial coronary artery disease (CAD) and left ventricular non-compaction (LVNC).
A 52-year-old male with acute coronary syndrome, in whom LVNC had been found "incidentally", was admitted for revascularisation. From a two-dimensional echocardiogram the epicardial layer appeared to be thin and compacted, but the apical endocardial layer of the left ventricle was extremely thickened with prominent trabeculations in the endocardial layer and deep intertrabecular recesses in a channel-like structure. Family history revealed that his 47-year-old brother also had LVNC but to a lesser degree. Their mother had two false tendons in the left ventricular apex and both parents had severe CAD.
Left ventricular non-compaction is "incidentally" identified in a kindred with familial CAD. The disease expressivity varies among affected individuals. Whether it is coincidental or there is a genetic link is a question that awaits further investigation. (Cardiol J 2007; 14: 407-410)
Get Citation

Keywords

coronary artery disease; non-compaction myocardium

About this article
Title

Case reports

Journal

Cardiology Journal

Issue

Vol 14, No 4 (2007)

Pages

407-410

Published online

2007-06-11

Bibliographic record

Cardiol J 2007;14(4):407-410.

Keywords

coronary artery disease
non-compaction myocardium

Authors

D. Bortolo Martini
Claudio Sperotto
Li Zhang

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