open access
Exercise stress test and comparison of ST change with cardiac nucleotide catabolite production in patients with coronary artery disease
open access
Abstract
Methods: Twenty-nine males with CAD and 11 controls without CAD (mean age 56.1 vs. 51.45) were subjected to treadmill exercise. The test was considered positive if ECG showed more then 1 mm ST segment depression. Venous blood samples taken before and 10 minut after the exercise were analysed by high performance liquid chromatography.
Results: Twenty-two out of 29 patients with CAD and 6 of 11 in the control group had abnormal exercise stress tests according to ECG criteria only. Mean ∆Ur was positive in the CAD group and negative in the control group (0.45 SEM ± 0.09 µM/L vs. -0.43 SEM ± 0.21 µM/L, p < 0.0001). ∆UA was positive in the CAD group (15.31 SEM ± 5.52 µM/L) and negative in the control group (15.31 SEM ± 5.52 µM/L vs. -48.18 SEM ± 13,8 µM/L, p < 0.00001); Hx increased in both groups, and the change was not significantly different. Correlations of CAD-index with ST depression, ∆Ur and ∆UA, were: r = 0.43 (p < 0.005), r = 0.62 (p < 0.001), and r = 0.39 (p < 0.01), respectively. Sensitivity of any increase of uridine was superior to 1.5 mm ST depression during exercise. Conclusions: Blood Ur and UA concentration changes during exercise correlate with severity of CAD. We observed slightly greater accuracy of uridine change in comparison to ST changes, thus being a possible new tool in diagnosis of CAD. (Cardiol J 2007; 14: 573-579).
Abstract
Methods: Twenty-nine males with CAD and 11 controls without CAD (mean age 56.1 vs. 51.45) were subjected to treadmill exercise. The test was considered positive if ECG showed more then 1 mm ST segment depression. Venous blood samples taken before and 10 minut after the exercise were analysed by high performance liquid chromatography.
Results: Twenty-two out of 29 patients with CAD and 6 of 11 in the control group had abnormal exercise stress tests according to ECG criteria only. Mean ∆Ur was positive in the CAD group and negative in the control group (0.45 SEM ± 0.09 µM/L vs. -0.43 SEM ± 0.21 µM/L, p < 0.0001). ∆UA was positive in the CAD group (15.31 SEM ± 5.52 µM/L) and negative in the control group (15.31 SEM ± 5.52 µM/L vs. -48.18 SEM ± 13,8 µM/L, p < 0.00001); Hx increased in both groups, and the change was not significantly different. Correlations of CAD-index with ST depression, ∆Ur and ∆UA, were: r = 0.43 (p < 0.005), r = 0.62 (p < 0.001), and r = 0.39 (p < 0.01), respectively. Sensitivity of any increase of uridine was superior to 1.5 mm ST depression during exercise. Conclusions: Blood Ur and UA concentration changes during exercise correlate with severity of CAD. We observed slightly greater accuracy of uridine change in comparison to ST changes, thus being a possible new tool in diagnosis of CAD. (Cardiol J 2007; 14: 573-579).
Keywords
exercise stress test; coronary artery disease; uridine; hypoxanthine; uric acid; pyrimidine and purine catabolism in the human heart
About this articleTitle
Exercise stress test and comparison of ST change with cardiac nucleotide catabolite production in patients with coronary artery disease
Journal
Issue
Pages
573-579
Published online
2007-10-10
Page views
611
Article views/downloads
1131
Bibliographic record
Cardiol J 2007;14(6):573-579.
Keywords
exercise stress test
coronary artery disease
uridine
hypoxanthine
uric acid
pyrimidine and purine catabolism in the human heart
Authors
Sławomir Burakowski
Ryszard T. Smoleński
Jerzy Bellwon
Andrzej Kubasik
Dariusz Ciećwierz
Andrzej Rynkiewicz
