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Vol 15, No 1 (2008)
Case Reports
Submitted: 2013-01-14
Published online: 2007-12-17
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Moxifloxacin-induced torsades de pointes

Saadia Sherazi, Michael DiSalle, James P. Daubert, Abrar H. Shah
Cardiol J 2008;15(1):71-73.

open access

Vol 15, No 1 (2008)
Case Reports
Submitted: 2013-01-14
Published online: 2007-12-17

Abstract

Torsade de pointes (TdP) is increasingly recognized as a complication of drug therapy. The most common cause of drug-induced QT prolongation is inhibition of the rapidly activating component of the delayed potassium current (IKr). Moxifloxacin, a widely used fluoroquinolone, is a weak IKr inhibitor and has been associated with QT prolongation. We report a case of marked QT prolongation (618 ms) and TdP associated with moxifloxacin use. Although it is difficult to predict which patients are at risk from TdP, careful assessment of the risk/benefit ratio is important before prescribing drugs known to cause QT prolongation. (Cardiol J 2008; 15: 71-73)

Abstract

Torsade de pointes (TdP) is increasingly recognized as a complication of drug therapy. The most common cause of drug-induced QT prolongation is inhibition of the rapidly activating component of the delayed potassium current (IKr). Moxifloxacin, a widely used fluoroquinolone, is a weak IKr inhibitor and has been associated with QT prolongation. We report a case of marked QT prolongation (618 ms) and TdP associated with moxifloxacin use. Although it is difficult to predict which patients are at risk from TdP, careful assessment of the risk/benefit ratio is important before prescribing drugs known to cause QT prolongation. (Cardiol J 2008; 15: 71-73)

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Keywords

torsade de pointes; moxifloxacin; QT prolongation

About this article
Title

Moxifloxacin-induced torsades de pointes

Journal

Cardiology Journal

Issue

Vol 15, No 1 (2008)

Pages

71-73

Published online

2007-12-17

Page views

636

Article views/downloads

1514

Bibliographic record

Cardiol J 2008;15(1):71-73.

Keywords

torsade de pointes
moxifloxacin
QT prolongation

Authors

Saadia Sherazi
Michael DiSalle
James P. Daubert
Abrar H. Shah

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