Vol 15, No 1 (2008)
Case Reports
Published online: 2007-12-17
Moxifloxacin-induced torsades de pointes
Cardiol J 2008;15(1):71-73.
Abstract
Torsade de pointes (TdP) is increasingly recognized as a complication of drug therapy. The
most common cause of drug-induced QT prolongation is inhibition of the rapidly activating
component of the delayed potassium current (IKr). Moxifloxacin, a widely used fluoroquinolone,
is a weak IKr inhibitor and has been associated with QT prolongation. We report a case of marked
QT prolongation (618 ms) and TdP associated with moxifloxacin use. Although it is difficult to
predict which patients are at risk from TdP, careful assessment of the risk/benefit ratio is important
before prescribing drugs known to cause QT prolongation. (Cardiol J 2008; 15: 71-73)
Keywords: torsade de pointesmoxifloxacinQT prolongation