open access

Vol 15, No 1 (2008)
Original articles
Published online: 2007-12-17
Submitted: 2013-01-14
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Study on the spatial distribution pattern of Cx40 gap junctions in the atria of patients with coronary heart disease

Zhou Sheng-hua, He Xian-zhi, Liu Qi-ming, Du Wang-hong, Li Xu-ping, Zhou Tao, Tang Jian-qun, Li Rong-shang
Cardiol J 2008;15(1):50-56.

open access

Vol 15, No 1 (2008)
Original articles
Published online: 2007-12-17
Submitted: 2013-01-14

Abstract

Background: The aim of this study was to evaluate the association between atrial fibrillation and atrial dilation and the spatial distribution pattern of connexin 40 in the atria of patients with coronary heart disease.
Methods: Twenty-six patients with coronary heart disease undergoing cardiac surgery for coronary artery bypass graft were investigated and were divided into three groups according to the left atrial size and rhythm, atrial fibrillation and left atrial dilatation (AF+AD), sinus rhythm and left atrial dilation (SR+AD) and sinus rhythm as control group SR. The spatial distribution patterns of Cx40 were evaluated using confocal laser scanning microscopy assay.
Results: No significant differences were observed in the size and density of Cx40 gap junction in the right atrium among all three groups (p > 0.05). Compared with the control group, the size of Cx40 disk area in termination links and in lateral abutment in left atrium was markedly larger in AF+AD group and SR+AD group than those of the controls (p < 0.01). A comparison of size and density of Cx40 gap junction in the left atrium in the AF+AD group and SR+AD group did not show significant differences.
Conclusions: The present study has shown altered gap junction distribution in coronary heart disease resulting from atrial dilation and atrial fibrillation. A decrease in the size and density of Cx40 gap junction was observed in patients with atrial dilation, which could be an important factor in the initiation and maintenance of atrial fibrillation. (Cardiol J 2008; 15: 50-56)

Abstract

Background: The aim of this study was to evaluate the association between atrial fibrillation and atrial dilation and the spatial distribution pattern of connexin 40 in the atria of patients with coronary heart disease.
Methods: Twenty-six patients with coronary heart disease undergoing cardiac surgery for coronary artery bypass graft were investigated and were divided into three groups according to the left atrial size and rhythm, atrial fibrillation and left atrial dilatation (AF+AD), sinus rhythm and left atrial dilation (SR+AD) and sinus rhythm as control group SR. The spatial distribution patterns of Cx40 were evaluated using confocal laser scanning microscopy assay.
Results: No significant differences were observed in the size and density of Cx40 gap junction in the right atrium among all three groups (p > 0.05). Compared with the control group, the size of Cx40 disk area in termination links and in lateral abutment in left atrium was markedly larger in AF+AD group and SR+AD group than those of the controls (p < 0.01). A comparison of size and density of Cx40 gap junction in the left atrium in the AF+AD group and SR+AD group did not show significant differences.
Conclusions: The present study has shown altered gap junction distribution in coronary heart disease resulting from atrial dilation and atrial fibrillation. A decrease in the size and density of Cx40 gap junction was observed in patients with atrial dilation, which could be an important factor in the initiation and maintenance of atrial fibrillation. (Cardiol J 2008; 15: 50-56)
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Keywords

coronary heart disease; atrial dilation; atrial fibrillation; connexin 40

About this article
Title

Study on the spatial distribution pattern of Cx40 gap junctions in the atria of patients with coronary heart disease

Journal

Cardiology Journal

Issue

Vol 15, No 1 (2008)

Pages

50-56

Published online

2007-12-17

Bibliographic record

Cardiol J 2008;15(1):50-56.

Keywords

coronary heart disease
atrial dilation
atrial fibrillation
connexin 40

Authors

Zhou Sheng-hua
He Xian-zhi
Liu Qi-ming
Du Wang-hong
Li Xu-ping
Zhou Tao
Tang Jian-qun
Li Rong-shang

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