Vol 15, No 1 (2008)
Original articles
Published online: 2007-12-17
The influence of permanent cardiac pacing on plasma levels of B-type natriuretic peptide in patients with sick sinus syndrome
Cardiol J 2008;15(1):39-42.
Abstract
Background: Unequivocal data presenting the impact of different pacing modes on B-type
natriuretic peptide levels has never been published. The aim of the study was to assess changes
of plasma B-type natriuretic peptide (BNP) during permanent cardiac pacing in patients with
sick sinus syndrome (SSS).
Methods: Patients with SSS undergoing routine pacemaker implantation were enrolled. Each subject underwent medical history and examination, echocardiography and blood sampling. Analysis was performed on 12 females (42.9%) and 16 males (57.1%), mean age 71.3 ± 9.03 years, range 49-90 years. There were 11 pacemakers with AAIR pacing mode (39.3%; AAI group) and 17 with DDDR mode (60.7%; DDD group) implanted. There were no significant differences in age, concomitant diseases or echocardiographic parameters between the groups in baseline characteristics or plasma BNP levels (94.05 ± 54.1 vs. 73.57 ± 70.13 pg/mL; p > 0.2).
Results: During six months follow-up no significant changes in plasma BNP levels in AAI group (94.05 ± 54.1 vs. 94.05 ± 54.1 pg/mL; p > 0.5) as well as in DDD group (73.57 ± 70.1 vs. 82.39 ± 58.9 pg/mL; p > 0.5) were noticed.
Conclusions: Atrial (AAIR) and dual chamber (DDDR) pacing did not influence plasma BNP levels in patients with SSS and preserved left ventricular systolic function. (Cardiol J 2008; 15: 39-42)
Methods: Patients with SSS undergoing routine pacemaker implantation were enrolled. Each subject underwent medical history and examination, echocardiography and blood sampling. Analysis was performed on 12 females (42.9%) and 16 males (57.1%), mean age 71.3 ± 9.03 years, range 49-90 years. There were 11 pacemakers with AAIR pacing mode (39.3%; AAI group) and 17 with DDDR mode (60.7%; DDD group) implanted. There were no significant differences in age, concomitant diseases or echocardiographic parameters between the groups in baseline characteristics or plasma BNP levels (94.05 ± 54.1 vs. 73.57 ± 70.13 pg/mL; p > 0.2).
Results: During six months follow-up no significant changes in plasma BNP levels in AAI group (94.05 ± 54.1 vs. 94.05 ± 54.1 pg/mL; p > 0.5) as well as in DDD group (73.57 ± 70.1 vs. 82.39 ± 58.9 pg/mL; p > 0.5) were noticed.
Conclusions: Atrial (AAIR) and dual chamber (DDDR) pacing did not influence plasma BNP levels in patients with SSS and preserved left ventricular systolic function. (Cardiol J 2008; 15: 39-42)
Keywords: sick sinus syndromeBNPpermanent cardiac pacing
