open access

Vol 15, No 3 (2008)
How to do
Published online: 2008-04-14
Submitted: 2013-01-14
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How to do exercise-induced T-wave alternans testing using the spectral method

Thomas Klingenheben, Paweł Ptaszyński
Cardiol J 2008;15(3):288-292.

open access

Vol 15, No 3 (2008)
How to do
Published online: 2008-04-14
Submitted: 2013-01-14

Abstract

The present review summarizes current aspects on how to perform noninvasive microvolt T-wave alternans (mTWA) testing in clinical practice. The focus is on methodologic issues such as patient-related, or technical aspects, and interpretation of the results. Special attention is given to the different sources of noise that may interfere with mTWA assessment. The role of beta-blocker therapy and its potential effect on mTWA is discussed as well. In the first clinical studies of mTWA, a high rate of indeterminate test results was observed. In this respect, patient-related indeterminacy has been demonstrated to be associated with an increased mortality and such tests are thus regarded as “abnormal” whereas technically inadequate tests are classified as indeterminate. Since mTWA evolves over time in patients with structural heart disease, the “optimal timing” for mTWA assessment is rather in the chronic phase than in the acute setting of heart disease. (Cardiol J 2008; 15: 288-292)

Abstract

The present review summarizes current aspects on how to perform noninvasive microvolt T-wave alternans (mTWA) testing in clinical practice. The focus is on methodologic issues such as patient-related, or technical aspects, and interpretation of the results. Special attention is given to the different sources of noise that may interfere with mTWA assessment. The role of beta-blocker therapy and its potential effect on mTWA is discussed as well. In the first clinical studies of mTWA, a high rate of indeterminate test results was observed. In this respect, patient-related indeterminacy has been demonstrated to be associated with an increased mortality and such tests are thus regarded as “abnormal” whereas technically inadequate tests are classified as indeterminate. Since mTWA evolves over time in patients with structural heart disease, the “optimal timing” for mTWA assessment is rather in the chronic phase than in the acute setting of heart disease. (Cardiol J 2008; 15: 288-292)
Get Citation

Keywords

arrhythmia risk stratification; microvolt T-wave alternans; methodology

About this article
Title

How to do exercise-induced T-wave alternans testing using the spectral method

Journal

Cardiology Journal

Issue

Vol 15, No 3 (2008)

Pages

288-292

Published online

2008-04-14

Bibliographic record

Cardiol J 2008;15(3):288-292.

Keywords

arrhythmia risk stratification
microvolt T-wave alternans
methodology

Authors

Thomas Klingenheben
Paweł Ptaszyński

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