open access

Vol 15, No 3 (2008)
Original articles
Published online: 2008-04-14
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Metaanalysis on effects of cardiac resynchronization therapy in heart failure patients with narrow QRS complex

Vinodh Jeevanantham, Wojciech Zaręba, Sankar Navaneethan, David Fitzgerald, Cheuk-Man Yu, Augusto Achilli, Jeroen Bax, James Daubert
Cardiol J 2008;15(3):230-236.

open access

Vol 15, No 3 (2008)
Original articles
Published online: 2008-04-14

Abstract

Background: To systematically review the benefits of cardiac resynchronization therapy (CRT) in heart failure patients with narrow QRS (< 120 ms) who have baseline mechanical asynchrony.
Methods: We searched the MEDLINE, Cochrane Central Register of Controlled Trials, and reference lists of retrieved articles for relevant trials through October 2007. Studies were included if they were clinical trials in heart failure patients with narrow QRS complex, had at least 3 months of duration and measured baseline mechanical dyssynchrony. Weighted mean difference (WMD) for changes in left ventricular ejection fraction (LVEF), New York Heart Association (NYHA) class and 6 minute walk distance (6MWD) at the end of follow up period were estimated using fixed effects meta-analysis.
Results: Three relevant clinical trials (enrolling 98 patients) out of 80 identified studies were included in the final analysis. When compared to baseline, CRT in heart failure patients with narrow QRS complex significantly improved mean LVEF (WMD 7.98%, 95% CI 5.94, 10.03) and 6MWD (WMD 67 m, 95% CI 39.12, 94.98) at the end of follow up period with no significant heterogeneity between the included studies (I2 < 50%). Similarly, there was a significant reduction in NYHA at the end of follow-up (WMD –0.87, 95% CI –1.01, –0.74) but there was significant heterogeneity between the included studies.
Conclusions: In patients with narrow QRS complex and baseline mechanical asynchrony, who underwent CRT after optimal medical management, there was a significant reduction in NYHA class, improvement in LVEF and increase in 6MWD during follow up. Further data from large randomized trials are warranted to explore the role of CRT in heart failure patients with narrow QRS complex. (Cardiol J 2008; 15: 230-236)

Abstract

Background: To systematically review the benefits of cardiac resynchronization therapy (CRT) in heart failure patients with narrow QRS (< 120 ms) who have baseline mechanical asynchrony.
Methods: We searched the MEDLINE, Cochrane Central Register of Controlled Trials, and reference lists of retrieved articles for relevant trials through October 2007. Studies were included if they were clinical trials in heart failure patients with narrow QRS complex, had at least 3 months of duration and measured baseline mechanical dyssynchrony. Weighted mean difference (WMD) for changes in left ventricular ejection fraction (LVEF), New York Heart Association (NYHA) class and 6 minute walk distance (6MWD) at the end of follow up period were estimated using fixed effects meta-analysis.
Results: Three relevant clinical trials (enrolling 98 patients) out of 80 identified studies were included in the final analysis. When compared to baseline, CRT in heart failure patients with narrow QRS complex significantly improved mean LVEF (WMD 7.98%, 95% CI 5.94, 10.03) and 6MWD (WMD 67 m, 95% CI 39.12, 94.98) at the end of follow up period with no significant heterogeneity between the included studies (I2 < 50%). Similarly, there was a significant reduction in NYHA at the end of follow-up (WMD –0.87, 95% CI –1.01, –0.74) but there was significant heterogeneity between the included studies.
Conclusions: In patients with narrow QRS complex and baseline mechanical asynchrony, who underwent CRT after optimal medical management, there was a significant reduction in NYHA class, improvement in LVEF and increase in 6MWD during follow up. Further data from large randomized trials are warranted to explore the role of CRT in heart failure patients with narrow QRS complex. (Cardiol J 2008; 15: 230-236)
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Keywords

cardiac resynchronization therapy; heart failure; narrow QRS

About this article
Title

Metaanalysis on effects of cardiac resynchronization therapy in heart failure patients with narrow QRS complex

Journal

Cardiology Journal

Issue

Vol 15, No 3 (2008)

Pages

230-236

Published online

2008-04-14

Bibliographic record

Cardiol J 2008;15(3):230-236.

Keywords

cardiac resynchronization therapy
heart failure
narrow QRS

Authors

Vinodh Jeevanantham
Wojciech Zaręba
Sankar Navaneethan
David Fitzgerald
Cheuk-Man Yu
Augusto Achilli
Jeroen Bax
James Daubert

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