open access

Vol 15, No 5 (2008)
Original articles
Published online: 2008-08-12
Submitted: 2013-01-14
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Restenosis is not associated with stent length in a pig model of coronary stent implantation

Michael Koutouzis, Apostolos Papalois, Stamatis Kyrzopoulos, Paraskevi Dafnomili, Zenon S Kyriakides
Cardiol J 2008;15(5):458-462.

open access

Vol 15, No 5 (2008)
Original articles
Published online: 2008-08-12
Submitted: 2013-01-14

Abstract


Background: The aim of this study was to determine if stent length is by itself a risk factor for intimal proliferation and restenosis. Long lesions represent an independent risk factor for restenosis after coronary stent implantation. A longer stented segment might result in a higher probability of restenosis.
Methods: Twenty-two 7-month-old male farm pigs underwent implantation of two steel stents, one short (8 mm length) and one long (16 mm length), in the right coronary artery. The pigs were sacrificed 28 days after stent implantation and histomorphometric analysis of the coronary arteries was performed for neointimal area proliferation and area stenosis evaluation.
Results: Seventeen short stents and 19 long stents were finally implanted. There were no differences in neointimal proliferation (1.84 ± 0.64 mm2 vs. 1.81 ± 0.94 mm2, p = 0.84), area stenosis (40 ± 9% vs. 41 ± 19%, p = 0.86) and lumen area (2.96 ± 1.30 mm2 vs. 2.51 ± ± 1.18 mm2, p = 0.21) between the short stent group and the long stent group, respectively.
Conclusions: These data suggest that stent length by itself does not influence restenosis extent in the porcine model.

Abstract


Background: The aim of this study was to determine if stent length is by itself a risk factor for intimal proliferation and restenosis. Long lesions represent an independent risk factor for restenosis after coronary stent implantation. A longer stented segment might result in a higher probability of restenosis.
Methods: Twenty-two 7-month-old male farm pigs underwent implantation of two steel stents, one short (8 mm length) and one long (16 mm length), in the right coronary artery. The pigs were sacrificed 28 days after stent implantation and histomorphometric analysis of the coronary arteries was performed for neointimal area proliferation and area stenosis evaluation.
Results: Seventeen short stents and 19 long stents were finally implanted. There were no differences in neointimal proliferation (1.84 ± 0.64 mm2 vs. 1.81 ± 0.94 mm2, p = 0.84), area stenosis (40 ± 9% vs. 41 ± 19%, p = 0.86) and lumen area (2.96 ± 1.30 mm2 vs. 2.51 ± ± 1.18 mm2, p = 0.21) between the short stent group and the long stent group, respectively.
Conclusions: These data suggest that stent length by itself does not influence restenosis extent in the porcine model.
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Keywords

restenosis; angioplasty; stent

About this article
Title

Restenosis is not associated with stent length in a pig model of coronary stent implantation

Journal

Cardiology Journal

Issue

Vol 15, No 5 (2008)

Pages

458-462

Published online

2008-08-12

Bibliographic record

Cardiol J 2008;15(5):458-462.

Keywords

restenosis
angioplasty
stent

Authors

Michael Koutouzis
Apostolos Papalois
Stamatis Kyrzopoulos
Paraskevi Dafnomili
Zenon S Kyriakides

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