open access

Vol 15, No 5 (2008)
Original articles
Published online: 2008-08-12
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C-reactive protein and coronary calcium score association in coronary artery disease

Ali Hosseinsabet, Ahmad Mohebbi, Alireza Almasi
Cardiol J 2008;15(5):431-436.

open access

Vol 15, No 5 (2008)
Original articles
Published online: 2008-08-12

Abstract

Background: Both high-sensitivity C-reactive protein (hs-CRP) and spiral computed tomography coronary artery calcium score (CCS) are valid markers of cardiovascular risk. It is unknown whether hs-CRP is a marker of atherosclerotic burden or whether it reflects a process leading to acute coronary events.
Methods and Results: We studied the relation between hs-CRP and CCS in 143 patients that were candidates for coronary artery bypass grafting (CABG). In our cross-sectional study, we found no significant association between hs-CRP and CCS in bivariate (p = 0.162) and multivariate (p = 0.062) analysis, but in patients who did not use statins this association was positive and significant in bivariate analysis (p = 0.001), and in multivariate analysis this association was negative and significant (p = 0.008).
Conclusions: High-sensitivity CRP was not correlated with CCS. The relation between CRP and clinical events might not be related to atherosclerotic burden. Measures of inflammation, such as hs-CRP, and indices of atherosclerosis, such as CCS, are likely to provide distinct information regarding cardiovascular risk.

Abstract

Background: Both high-sensitivity C-reactive protein (hs-CRP) and spiral computed tomography coronary artery calcium score (CCS) are valid markers of cardiovascular risk. It is unknown whether hs-CRP is a marker of atherosclerotic burden or whether it reflects a process leading to acute coronary events.
Methods and Results: We studied the relation between hs-CRP and CCS in 143 patients that were candidates for coronary artery bypass grafting (CABG). In our cross-sectional study, we found no significant association between hs-CRP and CCS in bivariate (p = 0.162) and multivariate (p = 0.062) analysis, but in patients who did not use statins this association was positive and significant in bivariate analysis (p = 0.001), and in multivariate analysis this association was negative and significant (p = 0.008).
Conclusions: High-sensitivity CRP was not correlated with CCS. The relation between CRP and clinical events might not be related to atherosclerotic burden. Measures of inflammation, such as hs-CRP, and indices of atherosclerosis, such as CCS, are likely to provide distinct information regarding cardiovascular risk.
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Keywords

coronary calcification; inflammation; risk factors; multislice spiral computed tomography; high-sensitivity C-reactive protein

About this article
Title

C-reactive protein and coronary calcium score association in coronary artery disease

Journal

Cardiology Journal

Issue

Vol 15, No 5 (2008)

Pages

431-436

Published online

2008-08-12

Bibliographic record

Cardiol J 2008;15(5):431-436.

Keywords

coronary calcification
inflammation
risk factors
multislice spiral computed tomography
high-sensitivity C-reactive protein

Authors

Ali Hosseinsabet
Ahmad Mohebbi
Alireza Almasi

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