open access

Vol 15, No 5 (2008)
Original articles
Published online: 2008-08-12
Submitted: 2013-01-14
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Effect of blood glucose levels on prognosis in acute myocardial infarction in patients with and without diabetes, undergoing percutaneous coronary intervention

Mariusz Gąsior, Damian Pres, Gabriela Stasik-Pres, Piotr Lech, Marek Gierlotka, Michał Hawranek, Krzysztof Wilczek, Bożena Szyguła-Jurkiewicz, Andrzej Lekston, Zbigniew Kalarus, Krzysztof Strojek, Janusz Gumprecht, Lech Poloński
Cardiol J 2008;15(5):422-430.

open access

Vol 15, No 5 (2008)
Original articles
Published online: 2008-08-12
Submitted: 2013-01-14

Abstract

Background: Diabetes mellitus (DM) is a significant factor regarding poor outcome in patients with myocardial infarction. Recently a new prognostic factor is under consideration - a baseline glucose level on admission. We sought to assess the influence of blood glucose levels on admission on prognosis of patients with acute ST-segment elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI).
Methods and results: Consecutive patients treated with PCI for STEMI were analyzed. Presence or absence of DM was the first grouping criterion. The secondary criterion was the blood glucose level on admission [threshold ≥ 7.8 mmol/L (140 mg/dL)]. Hyperglycemic and non-hyperglycemic subgroups were selected within both DM and non-DM groups according to the threshold. One-year mortality of diabetics was 16.0%. There was no significant difference in 1-year mortality between hyperglycemic and non-hyperglycemic patients with DM. One-year mortality in the non-DM group was 5.6%. Patients without DM but with hyperglycemia showed a higher 1-year mortality rate than non-hyperglycemic patients (8.51% vs. 3.68%, p = 0.001). Multivariate analysis revealed that in the non-DM group blood glucose level (per 1 mmol/L) on admission was a factor affecting 1-year mortality [HR = 1.09 (1.01–1.17)].
Conclusions: Elevated blood glucose levels in STEMI affect the prognosis of patients without DM; however, it is not an independent death risk factor of patients with DM treated with PCI.

Abstract

Background: Diabetes mellitus (DM) is a significant factor regarding poor outcome in patients with myocardial infarction. Recently a new prognostic factor is under consideration - a baseline glucose level on admission. We sought to assess the influence of blood glucose levels on admission on prognosis of patients with acute ST-segment elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI).
Methods and results: Consecutive patients treated with PCI for STEMI were analyzed. Presence or absence of DM was the first grouping criterion. The secondary criterion was the blood glucose level on admission [threshold ≥ 7.8 mmol/L (140 mg/dL)]. Hyperglycemic and non-hyperglycemic subgroups were selected within both DM and non-DM groups according to the threshold. One-year mortality of diabetics was 16.0%. There was no significant difference in 1-year mortality between hyperglycemic and non-hyperglycemic patients with DM. One-year mortality in the non-DM group was 5.6%. Patients without DM but with hyperglycemia showed a higher 1-year mortality rate than non-hyperglycemic patients (8.51% vs. 3.68%, p = 0.001). Multivariate analysis revealed that in the non-DM group blood glucose level (per 1 mmol/L) on admission was a factor affecting 1-year mortality [HR = 1.09 (1.01–1.17)].
Conclusions: Elevated blood glucose levels in STEMI affect the prognosis of patients without DM; however, it is not an independent death risk factor of patients with DM treated with PCI.
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Keywords

hyperglycemia; myocardial infarction; diabetes mellitus

About this article
Title

Effect of blood glucose levels on prognosis in acute myocardial infarction in patients with and without diabetes, undergoing percutaneous coronary intervention

Journal

Cardiology Journal

Issue

Vol 15, No 5 (2008)

Pages

422-430

Published online

2008-08-12

Bibliographic record

Cardiol J 2008;15(5):422-430.

Keywords

hyperglycemia
myocardial infarction
diabetes mellitus

Authors

Mariusz Gąsior
Damian Pres
Gabriela Stasik-Pres
Piotr Lech
Marek Gierlotka
Michał Hawranek
Krzysztof Wilczek
Bożena Szyguła-Jurkiewicz
Andrzej Lekston
Zbigniew Kalarus
Krzysztof Strojek
Janusz Gumprecht
Lech Poloński

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