Drug-induced QRS morphology and duration changes

John E. Madias

Vol 15, No 6 (2008)

Review Article

Submitted: 2013-01-14

Published online: 2008-09-22

View PDF

Download PDF file

Get Citation

Drug-induced QRS morphology and duration changes

John E. Madias

Cardiol J 2008;15(6):505-509.

Vol 15, No 6 (2008)

Review articles

Submitted: 2013-01-14

Published online: 2008-09-22

Abstract

Drug-induced ECG changes may affect all components of the ECG curve. The attention of regulatory agencies, researchers and clinicians has been directed towards drug-induced QT-interval prolongation and its well-documented proarrhythmia. This presentation focuses on druginduced changes, i.e., morphology, amplitude and QRS complex duration (QRSd). A great variety of pharmacological agents (e.g., class IA and IC antiarrhythmics, antihistamines, antidepressants, antipsychotics) exert an influence on the QRSd. The QRSd is assessed by a variety of ECG methodologies. Standardization of measurements of QRSd ensures the comparability of results by different ECG modalities, and of serial QRSd assessments. Some analgesics and hypoglycemic agents influence the amplitude of QRS complexes by way of their propensity to cause peripheral oedema (extracardiac mechanism). Perhaps a new culture could evolve in which the entire ECG curve, from the onset of the P-wave to the offset of the U-wave, will be used in the evaluation and monitoring of drug safety, with emphasis primarily on the standard ECG.

Abstract

Full Text:

View PDF

Download PDF file

Get Citation

Keywords

ECG; QRS duration; drug-induced ECG changes; drug-induced QRS duration changes; drug-induced QRS morphology changes; drug-induced QRS amplitude changes