open access

Vol 16, No 1 (2009)
Original articles
Published online: 2008-11-28
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Sustained benefit of left ventricular remodelling after valve replacement for aortic stenosis

Jose Antonio Linares-Vicente, Isaac Lacambra-Blasco, Pilar Portero-Perez, Maria Rosario Ortas-Nadal, Borja Simo-Sanchez, Isaac Pascual-Calleja, Jose Ramón Ruiz-Arroyo, Mariano González-Carretero, Alfonso Del-Rio-Ligorit
Cardiol J 2009;16(1):68-72.

open access

Vol 16, No 1 (2009)
Original articles
Published online: 2008-11-28

Abstract


Background: Valve replacement for aortic stenosis (AS) determines negative ventricular remodelling. We used cross sectional and Doppler echocardiography to check how rapidly it occurs and to assess if these changes are sustained over time.
Methods: We evaluated in 34 patients subjected to aortic valve replacement for AS morphological and functional (ejection fraction and E:A ratio) left ventricular data by echocardiography prior to surgery and 2 postoperative studies: early after surgery (pQ1) and at mid-term evolution (pQ2).
Results: Left ventricular mass index was reduced at pQ1 (from 152 ± 47 g/m2 to 113 ± 31 g/m2; p < 0.01) as well as end-diastolic (from 51.3 mm to 48.3 mm; p < 0.03), end-systolic (from 32.2 mm to 29.4 mm; p < 0.02), interventricular septum (from 12.9 mm to 10.3 mm; p < 0.01), and posterior wall (from 12.5 mm to 11 mm; p < 0.01) dimensions. Left ventricular ejection fraction (from 61.2% to 65.2%; p < 0.04) and E:A ratio (from 0.94 to 0.98; p < 0.01) increased significantly at pQ1. There were no significant differences in measurements between pQ1 and pQ2.
Conclusions: Aortic valve replacement surgery leads to a rapid negative left ventricular remodelling during the first 7 months, including a decrease in myocardial hypertrophy and an improvement in systolic and diastolic function. These beneficial hemodynamic changes are sustained for at least 3 years.

Abstract


Background: Valve replacement for aortic stenosis (AS) determines negative ventricular remodelling. We used cross sectional and Doppler echocardiography to check how rapidly it occurs and to assess if these changes are sustained over time.
Methods: We evaluated in 34 patients subjected to aortic valve replacement for AS morphological and functional (ejection fraction and E:A ratio) left ventricular data by echocardiography prior to surgery and 2 postoperative studies: early after surgery (pQ1) and at mid-term evolution (pQ2).
Results: Left ventricular mass index was reduced at pQ1 (from 152 ± 47 g/m2 to 113 ± 31 g/m2; p < 0.01) as well as end-diastolic (from 51.3 mm to 48.3 mm; p < 0.03), end-systolic (from 32.2 mm to 29.4 mm; p < 0.02), interventricular septum (from 12.9 mm to 10.3 mm; p < 0.01), and posterior wall (from 12.5 mm to 11 mm; p < 0.01) dimensions. Left ventricular ejection fraction (from 61.2% to 65.2%; p < 0.04) and E:A ratio (from 0.94 to 0.98; p < 0.01) increased significantly at pQ1. There were no significant differences in measurements between pQ1 and pQ2.
Conclusions: Aortic valve replacement surgery leads to a rapid negative left ventricular remodelling during the first 7 months, including a decrease in myocardial hypertrophy and an improvement in systolic and diastolic function. These beneficial hemodynamic changes are sustained for at least 3 years.
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Keywords

aortic stenosis; valve replacement; ventricular remodelling

About this article
Title

Sustained benefit of left ventricular remodelling after valve replacement for aortic stenosis

Journal

Cardiology Journal

Issue

Vol 16, No 1 (2009)

Pages

68-72

Published online

2008-11-28

Bibliographic record

Cardiol J 2009;16(1):68-72.

Keywords

aortic stenosis
valve replacement
ventricular remodelling

Authors

Jose Antonio Linares-Vicente
Isaac Lacambra-Blasco
Pilar Portero-Perez
Maria Rosario Ortas-Nadal
Borja Simo-Sanchez
Isaac Pascual-Calleja
Jose Ramón Ruiz-Arroyo
Mariano González-Carretero
Alfonso Del-Rio-Ligorit

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