open access

Vol 16, No 1 (2009)
Original articles
Submitted: 2013-01-14
Published online: 2008-11-28
Get Citation

Factors associated with C-reactive protein at the early stage of acute myocardial infarction in men

Katarzyna Piestrzeniewicz, Katarzyna Łuczak, Jan Henryk Goch
DOI: 10.5603/cj.21534
·
Cardiol J 2009;16(1):36-42.

open access

Vol 16, No 1 (2009)
Original articles
Submitted: 2013-01-14
Published online: 2008-11-28

Abstract


Background: Elevation of C-reactive protein (CRP) is associated with acute coronary events. CRP is related to cardiovascular risk factors and adipokines. The aim of the study was to reveal the factors associated with elevated CRP levels in patients with ST-segment elevation acute myocardial infarction (STEMI). As there are sex-related differences in plasma levels of CRP and adipokines, our study was designed for males.
Methods: Seventy men admitted within the initial 6 hours of STEMI were categorized into 4 groups according to the quartile of CRP. Clinical data and laboratory measurements were analyzed.
Results: Anthropometric measurements, glucose at admission, resistin, and leptin were significantly higher, and adiponectin lower with the increase of CRP quartile. A significant positive correlation between CRP and body mass index, waist circumference, glucose at admission, resistin, and leptin and a negative relation of CRP to HDL-cholesterol and adiponectin were observed. In univariate logistic regression analysis, variables associated with a level of CRP above the fourth quartile were history of angina, obesity, diabetes, glucose at admission, resistin, leptin, and adiponectin, and independent predictors were glucose at admission and resistin. To predict the elevated CRP level the optimal cut-off for glucose at admission was 144 mg/dL (sensitivity 84%, specificity 86%) and for resistin was 21.5 ng/mL (sensitivity 79%, specificity 71%).
Conclusions: Glucose at admission and resistin are independently associated with elevated levels of CRP in men during the early stage of STEMI.

Abstract


Background: Elevation of C-reactive protein (CRP) is associated with acute coronary events. CRP is related to cardiovascular risk factors and adipokines. The aim of the study was to reveal the factors associated with elevated CRP levels in patients with ST-segment elevation acute myocardial infarction (STEMI). As there are sex-related differences in plasma levels of CRP and adipokines, our study was designed for males.
Methods: Seventy men admitted within the initial 6 hours of STEMI were categorized into 4 groups according to the quartile of CRP. Clinical data and laboratory measurements were analyzed.
Results: Anthropometric measurements, glucose at admission, resistin, and leptin were significantly higher, and adiponectin lower with the increase of CRP quartile. A significant positive correlation between CRP and body mass index, waist circumference, glucose at admission, resistin, and leptin and a negative relation of CRP to HDL-cholesterol and adiponectin were observed. In univariate logistic regression analysis, variables associated with a level of CRP above the fourth quartile were history of angina, obesity, diabetes, glucose at admission, resistin, leptin, and adiponectin, and independent predictors were glucose at admission and resistin. To predict the elevated CRP level the optimal cut-off for glucose at admission was 144 mg/dL (sensitivity 84%, specificity 86%) and for resistin was 21.5 ng/mL (sensitivity 79%, specificity 71%).
Conclusions: Glucose at admission and resistin are independently associated with elevated levels of CRP in men during the early stage of STEMI.
Get Citation

Keywords

C-reactive protein; adipokines; myocardial infarction

About this article
Title

Factors associated with C-reactive protein at the early stage of acute myocardial infarction in men

Journal

Cardiology Journal

Issue

Vol 16, No 1 (2009)

Pages

36-42

Published online

2008-11-28

Page views

540

Article views/downloads

840

DOI

10.5603/cj.21534

Bibliographic record

Cardiol J 2009;16(1):36-42.

Keywords

C-reactive protein
adipokines
myocardial infarction

Authors

Katarzyna Piestrzeniewicz
Katarzyna Łuczak
Jan Henryk Goch

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By VM Media Group sp. z o.o., Grupa Via Medica, ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: viamedica@viamedica.pl