open access

Vol 16, No 3 (2009)
Original articles
Published online: 2009-03-10
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Reversible changes of electrocardiographic abnormalities after parathyroidectomy in patients with primary hyperparathyroidism

Oscar Vázquez-Díaz, Lilia Castillo-Martínez, Arturo Orea-Tejeda, Juan José Orozco-Gutiérrez, Enrique Asensio-Lafuente, Alfredo Reza-Albarrán, Rubén Silva-Tinoco, Verónica Rebollar-González
Cardiol J 2009;16(3):241-245.

open access

Vol 16, No 3 (2009)
Original articles
Published online: 2009-03-10

Abstract

Background: Several studies have reported that primary hyperparathyroidism is a risk factor of higher cardiovascular mortality, mainly because hyperparathyroidism is related to arterial hypertension, arrhythmias, structural heart abnormalities and activation of the renin–angiotensin– aldosterone system. However, very few studies have shown the electrocardiographic changes that occur after parathyroidectomy. That was the aim of this study.
Methods: We studied 57 consecutive patients with primary hyperparathyroidism surgically treated. Electrocardiogram, serum electrolytes, parathyroid hormone, creatinine and albumin measures were obtained before and after surgery and were compared.
Results: The most common basal electrocardiographic abnormalities were left ventricular hypertrophy (LVH, 24.6%), conduction disturbances (16.3%), and short QT and QTc intervals. After surgery, a QTc interval lengthening and a tendency of T wave shortening were observed, as well as an inverse association between QTc interval and serum levels of magnesium and corrected calcium. There were no differences in LVH and conduction disturbances after surgery.
Conclusions: Primary hyperparathyroidism is an important factor in the development of electrocardiographic abnormalities in this population, some of which are not corrected after parathyroidectomy. Further studies are required to demonstrate what factors are associated with persistence of electrocardiographic disturbances after surgery.

Abstract

Background: Several studies have reported that primary hyperparathyroidism is a risk factor of higher cardiovascular mortality, mainly because hyperparathyroidism is related to arterial hypertension, arrhythmias, structural heart abnormalities and activation of the renin–angiotensin– aldosterone system. However, very few studies have shown the electrocardiographic changes that occur after parathyroidectomy. That was the aim of this study.
Methods: We studied 57 consecutive patients with primary hyperparathyroidism surgically treated. Electrocardiogram, serum electrolytes, parathyroid hormone, creatinine and albumin measures were obtained before and after surgery and were compared.
Results: The most common basal electrocardiographic abnormalities were left ventricular hypertrophy (LVH, 24.6%), conduction disturbances (16.3%), and short QT and QTc intervals. After surgery, a QTc interval lengthening and a tendency of T wave shortening were observed, as well as an inverse association between QTc interval and serum levels of magnesium and corrected calcium. There were no differences in LVH and conduction disturbances after surgery.
Conclusions: Primary hyperparathyroidism is an important factor in the development of electrocardiographic abnormalities in this population, some of which are not corrected after parathyroidectomy. Further studies are required to demonstrate what factors are associated with persistence of electrocardiographic disturbances after surgery.
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Keywords

electrocardiogram; primary hyperparathyroidism; post parathyroidectomy

About this article
Title

Reversible changes of electrocardiographic abnormalities after parathyroidectomy in patients with primary hyperparathyroidism

Journal

Cardiology Journal

Issue

Vol 16, No 3 (2009)

Pages

241-245

Published online

2009-03-10

Bibliographic record

Cardiol J 2009;16(3):241-245.

Keywords

electrocardiogram
primary hyperparathyroidism
post parathyroidectomy

Authors

Oscar Vázquez-Díaz
Lilia Castillo-Martínez
Arturo Orea-Tejeda
Juan José Orozco-Gutiérrez
Enrique Asensio-Lafuente
Alfredo Reza-Albarrán
Rubén Silva-Tinoco
Verónica Rebollar-González

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